Teriparatide
Teriparatide is used to treat osteoporosis. It works by increasing the action of the bone formation cells, osteoblasts. This increases the formation of bone and therefore helps keep the bones strong. Teriparatide also increases the absorption of calcium from the intestine into the blood and the reabsorption of calcium from the kidneys into the blood. Calcium is deposited in the bone by the osteoblasts and this helps strengthen the bones.
Primary Characteristics
Molecular Weight: 4117.72 · Non-proprietary name: Teriparatide.
Pharmacokinetics
Elimination: it is metabolised via hepatic, plasma half-life is 1hr, renal excretion is Major.
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Indications
Teriparatide is primarily indicated in conditions like Osteoporosis, Osteoporosis in men, Osteoporosis in postmenopausal women.
Contraindications
Teriparatide is contraindicated in conditions like Hypercalcaemia, Pagets disease, Hyperparathyroidism, Pregnancy, Breast feeding.
Dosage
Teriparatide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 20 mcg | 20 mcg | Every 24h | SC | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Teriparatide is known to cause more or less tolerable side effects which are usually transient. These include Chest pain, Depression, Fatigue, Headache, Increased sweating, Muscle cramps, Nausea and vomiting, Pain , Redness, Shortening of breath, Swelling .
Warnings / Precautions
Interference in Pathology
Teriparatide may interfere in the diagnosis of Increases serum uric acid, Measurements of blood urea nitrogen (BUN), creatinine, and electrolytes in serum.
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.18.14 — Drugs affecting bone metabolism
Manufacturers
Manufacturers of Teriparatide in Pakistan: