Danazol
Danazol is an isoxazole derivative of ethisterone (17a-ethinyl testosterone). It has weak progestational and androgenic activities. It is a synthetic androgen (hormone). itused to treat pain and infertility caused by endometriosis (a condition involving the tissue of the uterus). italso used in the treatment of cysts or lumps in the breast.
Primary Characteristics
It is of Synthetic origin and belongs to Steroid.
It belongs to Aldosterone agonist pharmacological group on the basis of mechanism of action and also classified in Androgen pharmacological group. It is also classified under Sex Hormones .
Molecular Weight: 337.5 · Solubility in Water: nearly Insoluble · Solubility in Alcohol: sparingly soluble · Non-proprietary name: Danazol.
Pharmacokinetics
Absorption: Danazol has an oral bioavailability is 82.5% (±2.5%).
Elimination: it is metabolised via hepatic, plasma half-life is 2.6 hr, renal excretion is > 50%.
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Indications
Danazol is primarily indicated in conditions like Benign breast disease, Endometriosis, Gynaecomastia, Long term management of hereditary angioedema, Menorrhagia, Premenstrual syndrome, Severe pain and tenderness in benign fibrocystic breast disease, Treatment of endometriosis.
Danazol is also indicated for secondary conditions like Angioedema, Idiopathic thrombocytopenic purpura.
Contraindications
Danazol is contraindicated in conditions like Vaginal bleeding, Porphyria, Thrombo-embolic complications.
Dosage
Danazol's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 mg | 500 mg | — | PO | given in 2 divided doses daily for 3-6months. upto 9 months if necessary. |
| Paediatric Dosage (20kg) | ||||
| 10 – 40 | — | Every 24h | Oral | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Danazol in overdosage may give rise to further complications which include Hirsutism.
Danazol produces potentially life-threatening effects which include Hepatic dysfunction, Hepatic peliosis. Careful monitoring is needed with proper medical management.
Danazol is known to cause more or less tolerable side effects which are usually transient. These include Acne, Amenorrhea, Edema, Hair growth, Hot flushes, Oily skin, Sweating , Weight gain.
Warnings / Precautions
Interference in Pathology
Danazol may interfere in the diagnosis of Interferes with Thyroid Function Test .
Available Brands
Storage Conditions
Drug Classification
- 1.18.2 — Androgens