Dacarbazine
Dacarbazine is an antineoplastic drug. Dacarbazine is a synthetic compound that functions as an alkylating agent. All alkylating agents have or can form an alkyl group that becomes covalently bound to cellular constituents. Dacarbazine is effective in the treatment of different cancers to slow or stop the growth of abnormal or cancerous cells. Dacarbazine is used in combination with different anticancerous drugs to obtain excellent therapeutic effects and to minimize unwanted effects or toxicities.
Primary Characteristics
It is of Synthetic origin and belongs to Triazeno Imidazole.
It belongs to Alkylating Agents pharmacological group on the basis of mechanism of action and also classified in Antineoplastic Agent, Alkylating Agent pharmacological group.
Molecular Weight: 182.2 · pKa: 4.4 · Solubility in Water: > 1 in 1000 · Solubility in Alcohol: > 1 in 1000 · Non-proprietary name: Dacarbazine.
Pharmacokinetics
Distribution: Dacarbazine has a plasma protein binding is 5%.
Elimination: it is metabolised via Hepatic, plasma half-life is 5 hr, renal excretion is < 50%.
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Indications
Dacarbazine is primarily indicated in conditions like Hodgkin's disease, Malignant melanoma, Metastatic melanoma, Metastatic melanoma, Metastatic melanoma, Metastatic melanoma, Neuroendocrine tumors, Soft tissue sarcoma.
Contraindications
None recorded.
Dosage
Dacarbazine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 3.25 mg/kg | 3.25 mg/kg | Every 24h | IV | For 10 Days, repeated per month |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Dacarbazine in overdosage may give rise to further complications which include Photosensitivity .
Dacarbazine produces potentially life-threatening effects which include Hepatotoxicity , Moderate myelosuppression. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Dacarbazine are Severe myelosuppression.
Dacarbazine is known to cause more or less tolerable side effects which are usually transient. These include Alopecia, Diarrhea, Facial flushing, Facial paresthesia, Fever, Malaise, Myalgia, Nausea, Vomiting .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.8.2 — Cytotoxic (anti-neoplastic) drugs