Semustine

Also known as: Methyl Lomustine

Drug #2034

Semustine is a nitrosourea. It is one of group of antineoplastic drugs known as alkylating agent.

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Primary Characteristics

Semustine is also known as Methyl Lomustine.

Molecular Weight: 247.7 · Non-proprietary name: Semustine.

Pharmacokinetics

Elimination: it is metabolised via Rapid, plasma half-life is prolong, renal excretion is in urine as metabolite.

Indications

Semustine is primarily indicated in conditions like Brain tumors, Colorectal cancer, Lymphomas, Stomach cancer.

Contraindications

Semustine is contraindicated in conditions like Hypersensitivity.

Dosage

None recorded.

Drug Interactions

None recorded.

Side Effects

Semustine in overdosage may give rise to further complications which include Renal damage , Thrombocytopenia .

The signs and symptoms that are produced after acute overdosage of Semustine are Optic neuritis, Pulmonary fibrosis, Leucopenia , Convulsions .

Semustine is known to cause more or less tolerable side effects which are usually transient. These include Hyperpigmentation , Nausea and vomiting.

Warnings / Precautions

Used with caution in children who are at risk of severe delayed pul;monary toxicity, reduced lung function. Blood counts should be monitored weekly. Renal and hepatic functions should be monitored periodically.

Interference in Pathology

Semustine may interfere in the diagnosis of Monitoring of renal function, Monitoring of liver enzymes.

Available Brands

None recorded.

Storage Conditions

Semustine should be stored Inj.

Drug Classification

1.8.2 — Cytotoxic (anti-neoplastic) drugs