Cortisone (Acetate)

Drug #201

Cortisone (Acetate) is ester of cortisone, which is a natural glucocorticoid with a slight degree of mineralocoricoid activity. Chemically Cortisone (Acetate) is identified as 17, 21-Dihydroxypregn-4-ene-3, 11, 20-trione 21-acetate. It has slow onset but long duration of action. Cortisone (Acetate) is effective as an anti-infalmmatory and immunosuppressant in a wide variety of disorders. Administered orally or intramuscularly.

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Primary Characteristics

It is of Synthetic origin and belongs to Steroidal Hormone.

It belongs to Glucocorticoid agonist pharmacological group on the basis of mechanism of action and also classified in Corticosteroid Adrenal pharmacological group.

Molecular Weight: 402.5 · Solubility in Water: 1 in 5000 · Solubility in Alcohol: 1 in 300 · Non-proprietary name: Cortisone (Acetate).

Molecular structure of Cortisone (Acetate)

Pharmacokinetics

Absorption: Cortisone (Acetate) has an oral bioavailability is 97% (±2%).

Distribution: Cortisone (Acetate) has a volume of distribution is 0.3 l/kg. plasma protein binding is 95%.

Elimination: it is metabolised via >70% Hepatic, plasma half-life is 1.25 hr, renal excretion is readily.

Indications

Cortisone (Acetate) is primarily indicated in conditions like Adrenocortical insufficiency, Congenital adrenal hyperplasia.

Cortisone (Acetate) is also indicated for secondary conditions like Diarrhoea, Inflammation.

Contraindications

None recorded.

Dosage

Cortisone (Acetate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
25 mg/day	25 mg/day	Every 24h	PO	in divided doses with fludrocortisone allergic and inflamatory.
25 – 300 mg/day	—	Every 24h	PO/IM	in divided doses with fludrocortisone allergic and inflamatory.
Paediatric Dosage (20kg)
0.33 mg/kg	0.33 mg/kg	Every 8h	Oral	showrly disorders
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

8 interactions

Minor1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Cortisone (Acetate) in overdosage may give rise to further complications which include Skeletal deformation , Fracture , Avascular necrosis of bone , Muscle wasting , Inflammatory response suppression, Glaucoma , Diabetes , Osteoporosis , Depression , Posterior subcapsular cataract , Increased intracranial pressure , Increased IOP (intraocular pressure), Pancreatitis , Hypertension , Psychosis , Immune suppression , Supression of hypothalamic-pituitary-adrenal system.

Cortisone (Acetate) is known to cause more or less tolerable side effects which are usually transient. These include Acne, Body fat deposition, Bruising, Edema, Hirsutism , Moon face, Striae.

Warnings / Precautions

Cortisone acetate should be used with caution in patients with liver, kidney, heart or intestinal disease, hypothyroidism, high blood pressure, myasthenia gravis, osteoporosis (brittle bones), herpes eye infection or a history of tuberculosis (TB), seizures, ulcers, or blood clots and of any drug allergies. Do not have a vaccination, other immunization or any skin test while using cortisone, unless specifically recommended. It should be used with caution while taking aspirin, arthritis medicines or alcohol because; cortisones may make stomach and intestines more susceptible to the irritating effects of alcohol, aspirin and certain arthritis medications increasing the risk of ulcers. Report any injuries or signs of infection (fever, sore throat, pain during urination and muscle aches) that occur during treatment and within 12 months after treatment with cortisone, dose may need to be adjusted or may need to start taking the drug again. It should be used with extreme caution in diabetic patients because this drug may increase blood sugar level. Test urine for sugar (glucose) and contact the doctor if sugar is present in urine. Dose of diabetes medication and diet may need to be changed. This medication should be used only when clearly needed during pregnancy or lactation. Avoid use in infants because this medication can cause growth suppression in infants.

Interference in Pathology

Cortisone (Acetate) may interfere in the diagnosis of React with FeCl3 in measuring serum cholesterol .

Available Brands

None recorded.

Storage Conditions

Cortisone (Acetate) should be stored Tab, Inj.

Drug Classification

1.18.1 — Corticosteroids, systemic