Clopidogrel

Drug #2002

Clopidogrel is a thienopyridine antiplatelet drug used in thromboembolic disorders.it is an analogue of ticlopidine and acts by decreasing adenosine diphosphate-mediated platelet aggregation.

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Primary Characteristics

Clopidogrel is also known as Clopidogrel (Bisulphate).

It is of Synthetic origin and belongs to Ticlopidine.

Molecular Weight: 419.9 · Non-proprietary name: Clopidogrel.

Pharmacokinetics

Absorption: Clopidogrel has an oral bioavailability is 25% (±25%).

Distribution: Clopidogrel has a plasma protein binding is high.

Elimination: it is metabolised via hepatic, renal excretion is through urine and feces.

Indications

Clopidogrel is primarily indicated in conditions like Atherosclerosis, Myocardial infarction, Myocardial infarction prophylaxis, Peripheral arterial disease, Prophylaxis for NSAID-associated gastric and duodenal ulcers, Stroke, Stroke prophylaxis, Thrombo-embolic complications.

Clopidogrel is also indicated for secondary conditions like Angina, Unstable angina.

Contraindications

Clopidogrel is contraindicated in conditions like Peptic ulcer, Intracranial hemorrhage, Hypersensitivity.

Dosage

Clopidogrel's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
200 mg	200 mg	Every 24h	PO	administer with food if GI upset ocur.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown4 interactions

15 interactions

N/A2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Clopidogrel in overdosage may give rise to further complications which include Hepatitis , Oedema .

The signs and symptoms that are produced after acute overdosage of Clopidogrel are BLood dyscrasias.

Clopidogrel is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Arthralgia, Chest pain, Depression, Diarrhea, Dizziness, Dyspepsia , Epistaxis, Fatigue, GI disturbance, Headache, Influenza like syndrome , Nausea, Rashes , Skin RashX.

Warnings / Precautions

Use with caution in patients recieving other drugs that increase risk of bleeding including anticogulants,platelets and NSAIDS. It should be used with extreme caution in patients with history of bleeding disorder, or who may be at risk of increased bleeding from trauma, surgery or other pathalogical conditions, and patients with ulcers, liver problems or low blood count. If a patient is to undergo elective surgery and an antiplatelet effect is not desired, clopidrogel should be discontinued 7 days prior to surgery. It is classified as pregnancy category B and should be used with caution during pregnancy or lactation.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Tabs

150 mg 300 mg 7.5 mg 75 mg

Multi-Ingredient Combinations

Tabs

150 mg 75 mg

Storage Conditions

Clopidogrel should be stored .

Drug Classification

1.10.2 — Anticoagulants/Platelet deaggregators