Colestipol (HCl)

Drug #199

Colestipol (HCl) is antihyperlipidimic agent. Chemically Colestipol (HCl) is a copolymer of diethylenetriamine and 1-chloro-2, 3-epoxypropane. Colestipol (HCl) is very large polymeric anion-exchange resins that is insoluble in water. Colestipol (HCl) is effective in reducing the high levels of cholesterol in blood.

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Primary Characteristics

It is of Natural origin and belongs to Resin.

It belongs to Lipid lowering agents pharmacological group on the basis of mechanism of action.

Molecular Weight: 318.29 · Solubility in Alcohol: insoluble · Non-proprietary name: Colestipol (HCl) · pH: 6.

Pharmacokinetics

Elimination: renal excretion is < 0.05 %.

Indications

Colestipol (HCl) is primarily indicated in conditions like Atherosclerosis, Bile salt-induced diarrhoea, Digitalis toxicity, Digitoxin toxication, Familial hypercholesterolaemia, Hypercholesterolaemia, Partial biliary obstruction-induced pruritus, Prophylaxis of NSAID-associated gastric or duodenal ulcer, Prophylaxis of NSAID-associated gastric or duodenal ulcer.

Contraindications

Colestipol (HCl) is contraindicated in conditions like Intestinal obstruction, Diverticulitis, Anal fissure, Hernia.

Dosage

Colestipol (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
142.856 mg/kg	142.856 mg/kg	Every 12h	PO	2-16gm/day in divided doses
Paediatric Dosage (20kg)
0.375 g/kg	0.375 g/kg	Every 24h	Oral	Increase 0.25g/kg every 2-3 Months
Neonatal Dosage (3kg)
0 – 0	—	—		Not recomended in this age group

Drug Interactions

Unknown25 interactions

5 interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Colestipol (HCl) in overdosage may give rise to further complications which include Constipation .

The signs and symptoms that are produced after acute overdosage of Colestipol (HCl) are Intestinal obstruction.

Colestipol (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal discomfort, Constipation , Diarrhea, Flatulence, Heart burn, Nausea, Vomiting .

Warnings / Precautions

Before starting therapy, investigate and treat diseases like diabetes mellitus, hypothyroidism, dysproteinemias or liver diseases. With long term therapy, supplemental vitamin A and D may be given. Periodically measure serum triglyceride level to detect significant changes. These agents may produced or severely worsen pre-existing constipation. A laxatives, stool softener or increased fluid intake may be helpful.

Interference in Pathology

Colestipol (HCl) may interfere in the diagnosis of Increased Values for LFTs .

Available Brands

None recorded.

Storage Conditions

Colestipol (HCl) should be stored Tab.

Drug Classification

1.12.6 — Lipid-regulating drugs /Anti-atheromas