Metaxalone

Also known as: Methoxolone, Metazolone

Drug #1989

Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.

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Primary Characteristics

Metaxalone is also known as Methoxolone, Metazolone.

Molecular Weight: 221.25 · Solubility in Water: 1.28c+00g/l · Non-proprietary name: Metaxalone.

Pharmacokinetics

Elimination: it is metabolised via Hepatic, plasma half-life is 2-3 hr, renal excretion is In the urine as metabolise.

Indications

Metaxalone is primarily indicated in conditions like Painful musculoskeletal conditions.

Contraindications

Metaxalone is contraindicated in conditions like Anaemia, Impaired hepatic function, Impaired renal function, Hypersensitivity to any component of product.

Dosage

Metaxalone's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
800 mg	800 mg	—	PO	3-4 times a day
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

The signs and symptoms that are produced after acute overdosage of Metaxalone are Seizures, Leucopenia , Hemolytic anemia, Jaundice .

Metaxalone is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Drowsiness, Gastrointestinal disturbances, Headache, Irritability, Nausea and vomiting, Nervousness.

Warnings / Precautions

Metaxalone should be administered with great care to patients with pre-existing liver damage. Serial liver function studies should be performed in these patients. False-positive Benedict's tests, due to an unknown reducing substance, have been noted. A glucose-specific test will differentiate findings. Taking metaxalone with food may enhance general CNS depression; elderly patients may be especially susceptible to this CNS effect.

Interference in Pathology

Metaxalone may interfere in the diagnosis of False +ve Benedicts Test .

Available Brands

None recorded.

Storage Conditions

Metaxalone should be stored Tablets.

Drug Classification

1.2.2 — Opioid analgesics