Loxapine

Also known as: Loxapine Succinate, Cloxazepine, Loxitane

Drug #1972

Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.

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Primary Characteristics

Loxapine is also known as Loxapine Succinate, Cloxazepine, Loxitane.

It belongs to Dibenzoxazepine.

Molecular Weight: 327.81 · Non-proprietary name: Loxapine.

Pharmacokinetics

Elimination: plasma half-life is 4hrs, renal excretion is Urine (mainly).

Indications

Loxapine is primarily indicated in conditions like Psychotic illness, Schizophrenia.

Contraindications

Loxapine is contraindicated in conditions like Depression, Comatose states, Hypersensitivity to the drug.

Dosage

Loxapine's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
35 mg	35 mg	—		Initially in 2 divided doses.
80 mg	80 mg	—	PO	Maintainance to maximum of 250 mg.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Loxapine in overdosage may give rise to further complications which include Tardive dyskinesia , Akathisia .

The signs and symptoms that are produced after acute overdosage of Loxapine are Hypotension, Renal failure, CNS depression, Neuroleptic malignant syndrome.

Loxapine is known to cause more or less tolerable side effects which are usually transient. These include Agitation , dizziness, Drowsiness, Dyspnea, Facial flushing, Faintness , Headache, Insomnia, Light headedness, Nausea and vomiting, Pevasthesias, Polydipsia, Ptosis, Seborrhoea, Tension, Tremor, Weight gain, Weight loss.

Warnings / Precautions

Loxapine should be used with extreme caution in patients with a history of convulsive disorders, since it lowers the convulsive threshold. Seizures have been reported in epileptic patients receiving loxapine at antipsychotic dose levels and may occur even with maintenance of routine anticonvulsant drug therapy. Use loxapine with caution in patients with cardiovascular disease. Increased pulse rate and transient hypotension have both been reported in patients receiving antipsychotic doses. In the presence of severe hypotension requiring vasopressor therapy, the preferred drugs would be levarterenol or phenylephrine. Avoid the use of epinephrine in these cases. Although clinical experience has not demonstrated ocular toxicity, careful observation should be made for pigmentary retinopathy and lenticular pigmentation, since these have been observed in some patients receiving certain other antipsychotic drugs for prolonged periods.

Available Brands

None recorded.

Drug Classification

1.24.1 — Drugs used in psychotic disorders