Doxicycline Hyclate

Drug #1943

Doxicycline hyclate is a broad spectrum tetracycline antibiotic used against a wide variety of bacterial infections.It inhibits protein of symtoms by binding to 30s ribosome & prevent's addition of amino acid to growing peptide chain.

← Previous drug Next drug →

Primary Characteristics

Molecular Weight: 444.44 · Non-proprietary name: Doxicycline Hyclate.

Molecular structure of Doxicycline Hyclate

Pharmacokinetics

Absorption: Doxicycline Hyclate has an oral bioavailability is 46.5% (±46.5%).

Distribution: Doxicycline Hyclate has a volume of distribution is 0.9-1.8 l/kg. plasma protein binding is 90%.

Elimination: it is metabolised via not hepatic, plasma half-life is 18-22 hours, renal excretion is 30%faeces,23%urine.

Indications

Doxicycline Hyclate is primarily indicated in conditions like Anthrax, Bacterial infections, Chlamydial infections, Lyme disease, Plague, Rocky mountain spotted fever, Trachoma, Urinary tract infection.

Doxicycline Hyclate is also indicated for secondary conditions like Amoebic dysentry, Malaria, Periodontitis, Severe acne.

Contraindications

Doxicycline Hyclate is contraindicated in conditions like Hepatic dysfunction, Hypersensitivity.

Dosage

Doxicycline Hyclate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
200 mg	200 mg	—	oral	this dose should be given at 1st day than 100mg maintanance dose per day should be given.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Doxicycline Hyclate in overdosage may give rise to further complications which include Allergic reactions .

Doxicycline Hyclate produces potentially life-threatening effects which include Dyspepsia , Rash. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Doxicycline Hyclate are Nausea, Diarrhea, Anorexia .

Doxicycline Hyclate is known to cause more or less tolerable side effects which are usually transient. These include Angioedema, Inflammation, Itching, Loss of appetite, Rashes .

Warnings / Precautions

Doxycyclin hyclate should not be given with other antibiotics. While using Doxycyclin hyclate sunlight sensitivity may increase. By using Doxycyclin hyclate birth control pills may become less effective.

Interference in Pathology

Doxicycline Hyclate may interfere in the diagnosis of Liver Function Test (LFT) .

Available Brands

None recorded.

Storage Conditions

Doxicycline Hyclate should be stored .

Drug Classification

1.6.2.2.3 — Tetracyclines