Ziprasidone
Ziprasidone is a new antipsycotic drug with combined dopamine and serotinin receptor antagonist activity.
Primary Characteristics
Ziprasidone is also known as Ziprasidone HCL Monohydrate.
Molecular Weight: 412.94 · Non-proprietary name: Ziprasidone.
Pharmacokinetics
Distribution: Ziprasidone has a plasma protein binding is >99%.
Elimination: it is metabolised via hepatic, plasma half-life is 2-5 hours, renal excretion is 20% as metabolites,66% in feces.
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Indications
Ziprasidone is primarily indicated in conditions like Schizophrenia.
Ziprasidone is also indicated for secondary conditions like Depression, Mania, Tourette's syndrome.
Contraindications
Ziprasidone is contraindicated in conditions like Cardiac arrhythmia, Hypersensitivity reactions, QTc prolongation.
Dosage
Ziprasidone's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 25 mg | 25 mg | Every 12h | IM | Patient sholud switch therapy as soon as possible. |
| 90 mg | 90 mg | Every 12h | ORAL | Given every 2 days. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Ziprasidone in overdosage may give rise to further complications which include Fever , QT prolongation, Muscle twitching , Rashes.
Ziprasidone produces potentially life-threatening effects which include Seizures . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Ziprasidone are Sedation , Constipation, Somnolence, Dyspepsia.
Ziprasidone is known to cause more or less tolerable side effects which are usually transient. These include Agitation , Anxiety, Blood dyscrasias, Cholestatic Jaundice , Confusion, Dizziness, Extra pyramidal symptoms, GI disturbance, Headache, Hepatitis, Hyperglycemia, Hyperlipidemia, Hyperprolactinemia, Hypertension , Nausea, Obesity, Orthostatic hypotension, Seizures, Sexual dysfunction, Sneezing, Somnolence , Tardive dyskinesia.
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.24.1 — Drugs used in psychotic disorders