Guanfacine
Guanfacine is a centrally acting antihypertensive drug.It reduces systolic and dystolic blood pressure by decreasing level of certain chemicals in your blood. It may be used alone or with other antihypertensive.
Primary Characteristics
Molecular Weight: 282.6 · Non-proprietary name: Guanfacine.
Pharmacokinetics
Absorption: Guanfacine has an oral bioavailability is 40% (±40%).
Distribution: Guanfacine has a plasma protein binding is 71.6%.
Elimination: plasma half-life is 10-13 hr, renal excretion is urine.
Advertisement
Indications
Guanfacine is primarily indicated in conditions like Hypertension.
Guanfacine is also indicated for secondary conditions like Attention deficit hyperactivity disorder, Migraine, Opiate withdrawal syndrome.
Contraindications
Guanfacine is contraindicated in conditions like Hypersensitivity.
Dosage
Guanfacine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 – 2 mg/day | — | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
The signs and symptoms that are produced after acute overdosage of Guanfacine are Bradycardia, Hypotension, Diarrhea, Seizures.
Guanfacine is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Drowsiness, Dry mouth, Fatigue, Headache, Rebound hypertension on withdrawl.
Warnings / Precautions
Interference in Pathology
Guanfacine may interfere in the diagnosis of Abnormal LFTs .
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.6 — Centrally acting sympathoplegic drugs