Glutethimide
Also known as: Piperidiones
Glutethimide is a hypnotic sedative,that was introduced in 1954 as a safe alternative to barbiturates to treat insomnia.
Primary Characteristics
Glutethimide is also known as Piperidiones.
Molecular Weight: 217.26 · Non-proprietary name: Glutethimide.
Pharmacokinetics
Distribution: Glutethimide has a plasma protein binding is 50%.
Elimination: it is metabolised via hepatic, plasma half-life is 10-12 hours, renal excretion is 2%.
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Indications
Glutethimide is primarily indicated in conditions like Insomnia.
Glutethimide is also indicated for secondary conditions like Mydriasis induction.
Contraindications
Glutethimide is contraindicated in conditions like Peptic ulcer, Porphyria.
Dosage
Glutethimide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 500 mg | 500 mg | Every 24h | PO | Should be taken at bed time. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Glutethimide in overdosage may give rise to further complications which include Thrombocytopenia , Leucopenia, Agranulocytosis .
The signs and symptoms that are produced after acute overdosage of Glutethimide are Convulsions , Impairment of Consciousness, Respiratory depression, Shortness of breadth, Fever, Respiratory depression, Electrolyte disturbances, CNS depression, Weakness , Shortness of breadth, Respiratory depression.
Glutethimide is known to cause more or less tolerable side effects which are usually transient. These include Cramps , Dizziness, Drowsiness, Nausea and vomiting, Skin rash.
Warnings / Precautions
Interference in Pathology
Glutethimide may interfere in the diagnosis of False +ve phentolamine test.
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.24.3 — Drugs used in anxiety and sleep disorders