Edetic acid

Also known as: EDTA

Drug #1911

A chelating agent used mainly in the form of its salts for treatment of poisoning by substances such as heavy metals, cyanide, and Organophosphorus compounds. The salts form chelates with metal ions such as lead and mercury and promote the excretion of the metals from the body in a relatively nontoxic form.

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Primary Characteristics

Edetic acid is also known as EDTA.

Molecular Weight: 292.9 · Solubility in Water: insoluble · Solubility in Alcohol: insoluble · Non-proprietary name: Edetic acid.

Pharmacokinetics

Elimination: plasma half-life is 20-60min.

Indications

Edetic acid is primarily indicated in conditions like Anticoagulant.

Edetic acid is also indicated for secondary conditions like Digitalis induced arrythmias, Hypercalcaemia.

Contraindications

Edetic acid is contraindicated in conditions like Renal diseases, Anuria, Hepatitis, Pregnancy.

Dosage

None recorded.

Drug Interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Edetic acid produces potentially life-threatening effects which include Encephalopathy , Renal tubular damage, Cerebral edema. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Edetic acid are Broncho-constriction.

Warnings / Precautions

Urine flow must be monitored throughout therapy which must be stopped if anuria or severe oliguria develop. The proximal tubule hydropic degeneration usually recovers upon cessation of therapy. Calcium EDTA must be used in reduced doses in patients with pre-existing mild renal disease. Patients should be monitored for cardiac rhythm irregularities and other ECG changes during intravenous therapy.

Interference in Pathology

Edetic acid may interfere in the diagnosis of Urinanalysis , Decreased Value of Urinary Alkaline Phosphatase Test .

Available Brands

None recorded.

Drug Classification

1.4.2.3 — Organophosphate and carbamate poisoning