Brotizolam

Drug #1895

Brotizolam is a drug which is thienobenzodiazepine (a benzodiazepine derivative). It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties and is considered to be similar in effect to short-acting benzodiazepines such as triazolam. It is used in the short term treatment of insomnia although due to its short half life it is considered to have relatively high abuse potential and so would not be a first-line treatment.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 393.7 · Non-proprietary name: Brotizolam.

Pharmacokinetics

Distribution: Brotizolam has a plasma protein binding is 90%.

Elimination: it is metabolised via Hepatic, plasma half-life is 4.4 hours.

Indications

Brotizolam is primarily indicated in conditions like Insomnia.

Brotizolam is also indicated for secondary conditions like Premedication before surgery.

Contraindications

Brotizolam is contraindicated in conditions like Respiratory disease, Liver diseases, Close-angle glaucoma, Pregnancy, Lactation, Hypersensitivity to the drug.

Dosage

Brotizolam's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
1 mg	1 mg	—	oral
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Brotizolam in overdosage may give rise to further complications which include Urticaria , Dermatitis , Hypertension , Psychosis , Tachycardia , Jaundice .

Brotizolam is known to cause more or less tolerable side effects which are usually transient. These include Ataxia, Confusion, Depression, GI upset, Headache, Hypersalivation , Slurred speech, Somnolence .

Warnings / Precautions

Brotizolam should not be stopped abruptly. Sudden discontinuation may lead to withdrawal symptoms. The dosage should be gradually reduced in accordance with the advice of your doctor. Short-term therapy is advised and treatment should generally be no longer than 4 weeks, including a tapering off process. Do not take brotizolam for longer periods unless expressly instructed by your doctor.

Available Brands

None recorded.

Storage Conditions

Brotizolam should be stored Tabs.

Drug Classification

1.5 — Anticonvulsants and Antiepileptics
2.24.3 — Drugs used in anxiety and sleep disorders