Mazindol

Drug #1864

Mazindol is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an anorectic or an anorexigenic drug.It stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite. Sympathomimetic appetite suppressants are used in the short-term treatment of obesity. Their appetite-reducing effect tends to decrease after a few weeks. Because of this, these medicines are useful only during the first few weeks of a weight-loss program mazindol is thought to inhibit the reuptake of norepinephrine rather than to cause its release.

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Primary Characteristics

It is of Synthetic origin and belongs to Isoindole.

It is classified in Adrenergic Agonist Agent pharmacological group. It is also classified under CNS Stimulant .

Molecular Weight: 284.74 · Solubility in Water: insoluble · Solubility in Alcohol: slightly · Non-proprietary name: Mazindol.

Pharmacokinetics

Elimination: it is metabolised via Liver,extensive, plasma half-life is 10-13 hours, renal excretion is urine 39%.

Indications

Mazindol is primarily indicated in conditions like Obesity.

Mazindol is also indicated for secondary conditions like Narcolepsy.

Contraindications

Mazindol is contraindicated in conditions like Epilepsy, Hypertension, Hyperthyroidism, Cardiovascular disease, Arteriosclerosis.

Dosage

Mazindol's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
5.5 mg	5.5 mg	Every 24h	Oral	Mazindol should be taken before meal.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Mazindol in overdosage may give rise to further complications which include Allergic reactions , Restlessness , High blood pressure , Nervousness .

Mazindol produces potentially life-threatening effects which include ciculatory collapse. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Mazindol are Seizures, Hyperthermia, Hallucinations , Tremor, Agressive behavior, Arrhythmias.

Mazindol is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Insomnia, Irritability, Swelling of face, Vomiting .

Warnings / Precautions

Use caution while driving and operating machinery as it causes dizziness and tiredness. It is a habit forming drug so withdrawal effects occurs. It should be withdraw gradually.

Available Brands

None recorded.

Storage Conditions

Mazindol should be stored .

Drug Classification

1.21.4.3 — Sympathomimetics