DrugInfoSys

Cetrorelix

Drug #1840

Cetrorelix is luteinising hormone releasing hormone antagonist, which inhibits the release of gonadotrophins (luteinising hormone and follicle-stimulating hormone). It is used in the treatment of infertility by assisted reproductive techniques.

← Previous drugNext drug →

Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 1431.06 · Non-proprietary name: Cetrorelix.

Molecular structure of Cetrorelix

Pharmacokinetics

Absorption: Cetrorelix has an oral bioavailability is 42.5% (±42.5%).

Distribution: Cetrorelix has a plasma protein binding is 86%.

Elimination: plasma half-life is 60 hrs, renal excretion is faeces 5 -10% & urine 2-4%.

Advertisement

Indications

Cetrorelix is primarily indicated in conditions like Acute diarrhoea, Adjunct in the treatment of female infertilty (under specialist supervision).

Contraindications

Cetrorelix is contraindicated in conditions like Pregnancy, Breast feeding, Listerial meningitis (adjunct), Prophylaxis of gout.

Dosage

Cetrorelix's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
250 mcg250 mcg—SCIn tothe lower abdominal wall ,starting on day 5 or 6 of ovarian stimulation with gonadotophins (or each evening starting on day 5 of ovarian stimulation); continue throughout administration of gonadotrophin including day of ovulation induction. or 3mg on day 7 of ovarian stimulation with gonadotrophins;if ovulation induction is not possible on day 5 after 3mg dose,additional 250mcg once.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

None recorded.

Side Effects

Cetrorelix is known to cause more or less tolerable side effects which are usually transient. These include Headache, Hypersensitivity reactions, Injection site reactions, Nausea.

Warnings / Precautions

Special care should be taken in women with signs and symptoms of active allergic conditions or known history of allergic predisposition. Treatment with Cetrorelix is not advised in women with severe allergic conditions. Drinking alcoholic beverages or smoking tobacco may decrease chances of becoming pregnant. Talk with your health care professional about not drinking alcohol and decreasing tobacco use during your fertility treatments.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Inj
0.25 mg3 mg

Storage Conditions

Cetrorelix should be stored Inj.

Drug Classification

  1. 1.18.2 — Androgens

Manufacturers

Manufacturers of Cetrorelix in Pakistan:

Merck