Pemoline

Drug #1834

Pemoline is a central stimulant, has been used in the management of hyperactivity disorders in children. Choreoathetosis and rhabdomyolysis developed in a patient following a marked increase in intake of Pemoline.

← Previous drug Next drug →

Primary Characteristics

Molecular Weight: 176.2 · Non-proprietary name: Pemoline.

Pharmacokinetics

Distribution: Pemoline has a plasma protein binding is 50%.

Elimination: it is metabolised via Partially hepatic, plasma half-life is 12 hrs.

Indications

Pemoline is primarily indicated in conditions like Labyrinthine disorders, Prostate cancer, long-term palliative therapy.

Contraindications

Pemoline is contraindicated in conditions like Liver diseases.

Dosage

Pemoline's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
65.625 mg/day	65.625 mg/day	—	PO	The recommended starting dose is 37.5 mg/day. The maximum recommended daily dose of pemoline is 112.5 mg.
Paediatric Dosage (20kg)
75 – 56.25 mg	—	Every 24h	PO	The max. recommended daily dose is 112.5 mg.
Neonatal Dosage (3kg)
No data.

Drug Interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Pemoline in overdosage may give rise to further complications which include Growth inhibition , Mania .

The signs and symptoms that are produced after acute overdosage of Pemoline are Choreoathetosis, Chorea, Rhabdomyolysis .

Pemoline is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Fever, Neutropenia, Tics.

Warnings / Precautions

Pemoline should be used only after other treatments have failed. If this drug fails to work within a reasonable amount of time (within 3 weeks after ideal dosage has been determined) its use should be stopped. This medication has rarely caused severe (sometimes fatal) liver problems.Pemoline should be used only after other treatments have failed. If this drug fails to work within a reasonable amount of time (within 3 weeks after ideal dosage has been determined) its use should be stopped. This medication has rarely caused severe (sometimes fatal) liver problems.

Interference in Pathology

Pemoline may interfere in the diagnosis of Liver Function Test (LFT) .

Available Brands

None recorded.

Drug Classification

1.21.4.3 — Sympathomimetics