Clodronate

Drug #183

Clodronate used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy.

Primary Characteristics

It is of Synthetic origin and belongs to Geminal Biphosphonate.

It belongs to Osteoclast inhibitor pharmacological group on the basis of mechanism of action and also classified in Diphophonate pharmacological group.

Molecular Weight: 288.9 · pK_a: 1.0, 1.38,1.8, 6, 9.5 · Solubility in Water: soluble · Non-proprietary name: Clodronate.

Pharmacokinetics

Absorption: Clodronate has an oral bioavailability is 2.5% (±1.5%).

Distribution: Clodronate has a volume of distribution is 16 - 33 litre. plasma protein binding is low.

Elimination: it is metabolised via not metabolizied in human, plasma half-life is 2hr, renal excretion is 75%.

Indications

Clodronate is primarily indicated in conditions like Hypercalcaemia due to malignancy, Osteolytic bone metastases, Pagets disease.

Contraindications

Clodronate is contraindicated in conditions like Renal insufficiency, Hypersensitivity.

Dosage

Clodronate's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
400 mg	400 mg	Every 24h	capsule
800 mg	800 mg	Every 24h	tablet
Paediatric Dosage (20kg)
0 – 0	—	—		Safety not established
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown1 interaction

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Clodronate in overdosage may give rise to further complications which include Secondary hyperparathyroidism .

Clodronate produces potentially life-threatening effects which include Acute Renal Failure . Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Clodronate are Hypoglycemia, Acute renal failure.

Clodronate is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, GI upset, Hypocalcemia, Nausea, Vomiting .

Warnings / Precautions

Adequate fluid intake must be maintained during clodronate treatment. This is particularly important when administering clodronate as intravenous infusion and in patients with hypercalcemia or renal failure. Intravenous administration of doses notably higher than those recommended may cause severe renal damage especially if the infusion rate is too high.

Interference in Pathology

Clodronate may interfere in the diagnosis of Bone scintigraphy examinations.

Available Brands

None recorded.

Storage Conditions

Clodronate should be stored .

Drug Classification

1.18.14 — Drugs affecting bone metabolism