Exemestane
A steroidal aromatase inhibitor, used in the treatment of advanced breast cancer in postmenopausal women in whom anti-estrogen therapy has failed.
Primary Characteristics
It is of Synthetic origin.
Non-proprietary name: Exemestane.
Pharmacokinetics
Elimination: it is metabolised via in liver, plasma half-life is 2 hrs.
Advertisement
Indications
Exemestane is primarily indicated in conditions like Male hypersexuality.
Exemestane is also indicated for secondary conditions like Breast cancer.
Contraindications
Exemestane is contraindicated in conditions like Premenopausal breast cancer, Pregnancy, Breast feeding.
Dosage
Exemestane's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 25 mg | 25 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Exemestane in overdosage may give rise to further complications which include Tumors.
Exemestane produces potentially life-threatening effects which include Breast cancer. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Exemestane are Nausea, Faligue.
Exemestane is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Alopecia, Anorexia , Constipation , Depression, dizziness, Dyspepsia , Fatigue, Headache, Hot flushes, Insomnia, Leucopenia, Nausea, Peripheral edema, Rashes , Sweating , Thrombocytopenia, Vomiting .
Warnings / Precautions
Interference in Pathology
Exemestane may interfere in the diagnosis of Elevations of SGPT and SGOT , Increased Alkaline Phosphatase Levels, Increased in serum creatinin.
Available Brands
Click on a strength to view available brands.
Single Ingredient
Drug Classification
- 1.8.3 — Hormones and antihormones
Manufacturers
Manufacturers of Exemestane in Pakistan: