DrugInfoSys

Gatifloxacin

Drug #1761

Gatifloxacin is an antibiotic belongs to 3rd group of fluoroquinolones. Fluoroquinolones are potent bactericidal agents against E. coli and various species of Salmonella, Shigella, Enterobacter, Campylobacter and Neisseeria, it has excellent activity against S. pneumoniae. Gatifloxacin is used in respiratory tract infections, in urinary tract infectionsand in bone and soft tissue infections.

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Primary Characteristics

It is of Synthetic origin and belongs to Fluoroquinolones.

Molecular Weight: 402.4 · Non-proprietary name: Gatifloxacin.

Molecular structure of Gatifloxacin

Pharmacokinetics

Absorption: Gatifloxacin has an oral bioavailability is 96%.

Distribution: Gatifloxacin has a volume of distribution is 1.5-2.0. plasma protein binding is 20%.

Elimination: plasma half-life is 8 hr , 7-14 hrs, renal excretion is 83.2 +/- 4.0.

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Indications

Gatifloxacin is primarily indicated in conditions like Infections caused by Gram +ve organisms (particularly S.pneumoniae and to some extent staphylococci), Respiratory tract infections, Skin structure infections, Soft tissue infections, Uncomplicated skin, UTI.

Contraindications

Gatifloxacin is contraindicated in conditions like Diabetes mellitus, Hypersensitivity to the drug.

Dosage

Gatifloxacin's dosage details are as follows:

DoseSingle DoseFrequencyRouteInstructions
Adult Dosage
0.3 %0.3 %Every 0.4hIV inf (eye drops)
200 – 400 mg—Every 24hPOFor uncomplicated urinary tract infections for 3 days
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Gatifloxacin produces potentially life-threatening effects which include Coma, Convulsions , Diabetic ketoacidosis, Hyperosmolar non-ketotic hyperglycaemic coma. Careful monitoring is needed with proper medical management.

Gatifloxacin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal discomfort, Abnormal LFT, Diarrhea, Dizziness, Hyperglycemia in diabetic patients, Hypoglycemia in patients also receiving oral hypoglycaemic agents, Insomnia, Nausea and vomiting, QT prolongation, Skin RashX.

Warnings / Precautions

Fluoroquinolones should be used with caution in patients with a history of epilepsy or conditions that predisposed to seizures, in G6PD deficiency, myasthenia gravis (risk of exacerbation), in pregnancy, during breast-feeding, and in children or adolescents (arthropathy has developed in weight bearing joints in young animals. Exposure to sunlight should be avoided (discontinue if photosensitivity occurs). The CSM has warned that quinolones may induce convulsions in patients with or without convulsions; taking NSAIDs at the same time may also induce them. USE IN CHILDREN: Quinolones cause athropathy in the weight-bearing joints of immature animals and are therefore generally not recommended in the children and growing adolescents. However, the significance of this effect in human is uncertain and in some specific circumstances short-term use of a quinolone in children may be justified. Gatifloxacin should not be givento diabetic patients.

Interference in Pathology

Gatifloxacin may interfere in the diagnosis of Elevation in ALT or AST.

Available Brands

Click on a strength to view available brands.

Single Ingredient

Drops
5 mg/ml
Eye Drops
0.3 %w/v
Eye Oint
0.3 %w/w
Inf
2 mg/ml
Tabs
200 mg250 mg400 mg500 mg

Drug Classification

  1. 1.6.2.2.2 — Quinolones

Manufacturers