Modafinil

Drug #1746

Modafinil is a centralnervous system (CNS) stimulant and alpha1-adrenergic agonist chemically related to adrafinil. Modafinil is used in the treatment of narcoleptic syndrome.

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Primary Characteristics

Molecular Weight: 273.3 · Solubility in Water: Insoluble in water · Solubility in Alcohol: Sparingly to slighlty soluble · Non-proprietary name: Modafinil.

Pharmacokinetics

Absorption: Modafinil has an pre-systemic (first-pass) metabolism accounts for 83% (±7%).

Distribution: Modafinil has a volume of distribution is 0.78(0.69-0.87)l/kg or 0.9l/kg. plasma protein binding is 60%.

Elimination: plasma half-life is 10.5(9-12)hr, renal excretion is 3.7(11.3-18.7)%.

Indications

Modafinil is primarily indicated in conditions like Narcolepsy, Sleep apnea syndrome.

Contraindications

Modafinil is contraindicated in conditions like Pregnancy, Breast feeding, Myocardial infarction (non st-segment elevation), Hypertension of pregnancy, Hypertension with angina.

Dosage

Modafinil's dosage details are as follows:

Dose	Single Dose	Frequency	Route
Adult Dosage
300 mg	300 mg	Every 24h	PO
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Modafinil is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Anxiety, Buccofacial dyskinesia, CNS stimulation, Depression, Dry mouth, Euphoria, Excitation , Gastric discomfort, GI disturbance, Hallucination , Headache, Hypertension , Insomnia, Nausea, Nervousness, Palpitation, Personality disorders, Pruritus , Psychosis, Rashes , Tachycardia, Tremor.

Warnings / Precautions

Modafinil should be used with caution in patients with hepatic impairment (halve dose in severe liver disease); renal impairment (use half normal dose, if severe); monitor blood pressure and heart rate in hypertensive patients; possibility of dependence..Avoid alcohalic beverages.This medicine should be used only when clearly needed during pregnancy,discuses the risk and benefits with your doctor.Consult your dr before feeding. Not use for paediatrics in any indication.

Available Brands

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Single Ingredient

Tabs

100 mg 200 mg

Storage Conditions

Modafinil should be stored Oral tablets.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders

Manufacturers

Manufacturers of Modafinil in Pakistan:

Jawa Wilshire