Butobarbital

Also known as: Butobarbitone, Butabarbital

Drug #1742

Butobarbital is a barbiturate with general properties similar to amylobarbital. Butobarbital is now rarely used due to associated risk of adverse effects and dependence.

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Primary Characteristics

Butobarbital is also known as Butobarbitone, Butabarbital.

It is of Synthetic origin and belongs to Barbiturates.

Molecular Weight: 212.2 · Solubility in Water: 136mg/L · Non-proprietary name: Butobarbital.

Pharmacokinetics

Distribution: Butobarbital has a plasma protein binding is 20%.

Elimination: it is metabolised via Hepatic, plasma half-life is 40-55 hrs, renal excretion is major.

Indications

Butobarbital is primarily indicated in conditions like Hypnotic, Sedative.

Butobarbital is also indicated for secondary conditions like Cerebrovascular disease, Epilepsy.

Contraindications

Butobarbital is contraindicated in conditions like Porphyria, Pregnancy, Breast feeding, Heterozygous familial hypercholesterolaemia, Hyperlipidaemias, see instruction, Central retinal venous/arterial thrombosis.

Dosage

Butobarbital's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
22.5 mg	22.5 mg	Every 8h	PO	Dose for sedation maintenance (routine daytime sedation), to relieve anxiety, tension or apprehension.
75 mg	75 mg	—	PO	Dose for the short term treatment of insomnia and is given at bed time.
75 mg	75 mg	—	PO	Dose for preprocedure sedation induction and relief of preoperative anxiety and is given 60-9 minutes before surgery.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Butobarbital is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Hangover with drowsiness, Headache, Hypersensitivity reactions, Paradoxical excitement, Precede sleep, Respiratory depression.

Warnings / Precautions

Avoid use where possible; dependence and tolerance readily occur,abrupt withdrawl may precipitate serious withdrawl syndrome (rebound insomnia ,anxiety, tremor, dizziness, nausea, convulsions, delirium, and death), repeated doses are cumulative and may lead to excessive sedation, respiratory disease, renal disease, hepatic impairment. DRIVING: Drowsiness may persist the next day and affect performance of the skilled tasks (e.g driving); effects of alcohol enhanced.

Available Brands

None recorded.

Storage Conditions

Butobarbital should be stored Tabs.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders