Amobarbital

Also known as: Amylobarbitone

Drug #1741

Amobarbital is a barbiturate, used as a hypnotic and sedative. Amobarbital is now rarely recommended because of its adverse side effects and dependence.

← Previous drug Next drug →

Primary Characteristics

Amobarbital is also known as Amylobarbitone.

It is of Synthetic origin.

Molecular Weight: 226.13 · Solubility in Water: 8.97e-01mg/mL · Non-proprietary name: Amobarbital.

Pharmacokinetics

Elimination: it is metabolised via Hepatic, plasma half-life is 8-42 hrs.

Indications

Amobarbital is primarily indicated in conditions like Prophylaxis of NSAID-associated gastric or duodenal ulcer.

Contraindications

Amobarbital is contraindicated in conditions like Porphyria, Pregnancy, Breast feeding, Heterozygous familial hypercholesterolaemia, Hyperlipidaemias, see instruction, Central retinal venous/arterial thrombosis.

Dosage

Amobarbital's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
40 mg	40 mg	—	IM/IV	This dose is for day time sedation. To be taken 2-3 times a day.
132.5 mg/dose	132.5 mg/dose	—	IV	This dose is for control of seizures.
132.5 mg	132.5 mg	—	IV/IM	This dose is for trouble in sleeping. Should be injected into a muscle or vein.
132.5 mg	132.5 mg	—	PO	This dose is for trouble in sleeping. Should be taken at bed time.
175 mg	175 mg	—	PO	This dose is for day time sedation. Should be taken in smaller doses during the day.
200 mg	200 mg	—	PO	This dose is for sedation before surgery. Should be taken 1 to 2 hours before surgery..
300 mg	300 mg	—	PO	This dose is for sedation during labour. To be taken every one to three hours if needed. However, the total dose is usually not more than 1000 mg.
Paediatric Dosage (20kg)
0 – 0	—	—
Neonatal Dosage (3kg)
No data.

Drug Interactions

7 interactions

Major9 interactions

Moderate2 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Amobarbital is known to cause more or less tolerable side effects which are usually transient. These include Ataxia, Confusion, Dizziness, Hangover with drowsiness, Headache, Hypersensitivity reactions, Paradoxical excitement, Precede sleep, Respiratory depression.

Warnings / Precautions

Avoid use where possible; dependence and tolerance readily occur,abrupt withdrawl may precipitate serious withdrawl syndrome (rebound insomnia ,anxiety, tremor, dizziness, nausea, convulsions, delirium, and death), repeated doses are cumulative and may lead to excessive sedation, respiratory disease, renal disease, hepatic impairment. DRIVING: Drowsiness may persist the next day and affect performance of the skilled tasks (e.g driving); effects of alcohol enhanced.

Available Brands

None recorded.

Storage Conditions

Amobarbital should be stored Tabs,Caps.

Drug Classification

1.24.3 — Drugs used in anxiety and sleep disorders