Cinnarizine
Cinnarizine is antihistaminic agent. Cinnarizine is mainly used for treatment of vomiting and vertigo.
Primary Characteristics
It is of Synthetic origin and belongs to Phenyl piperazine.
It belongs to Calcium L-channel antagonist pharmacological group on the basis of mechanism of action.
Molecular Weight: 368.5 · Solubility in Water: insoluble · Solubility in Alcohol: 1 in 100 · Non-proprietary name: Cinnarizine.
Pharmacokinetics
Elimination: it is metabolised via extensive, plasma half-life is 3-6hr, renal excretion is 16.6 ± 7.5%.
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Indications
Cinnarizine is primarily indicated in conditions like Motion sickness, Peripheral arterial disease, Peripheral vascular disease, Raynaud`s syndrome, Vestibular disorders, Vestibular symptoms of central and peripheral origin.
Cinnarizine is also indicated for secondary conditions like Nausea and vomiting, Raynaud's disease, Vertigo.
Contraindications
Cinnarizine is contraindicated in conditions like Hypotension, Parkinson's disease.
Dosage
Cinnarizine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | Every 8h | PO | In Motion sickness half an hour before travelling. |
| Paediatric Dosage (20kg) | ||||
| 0.6 mg/kg | 0.6 mg/kg | Every 8h | Oral | Not recommended for below 5 yrs. Dose for 5-12 Yrs of Children |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended under 5 yrs.of children | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cinnarizine in overdosage may give rise to further complications which include Extrapyramidal symptoms, Tardive dyskinesia , Parkinsonism .
Cinnarizine produces potentially life-threatening effects which include Respiratory depression, Convulsions , Drowsiness , In wordination. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Cinnarizine are Respiratory depression, Drowsiness, Dizziness, Respiratory depression, Incoordination , Respiratory depression, Drowsiness, Hypopyrexia, Convulsions .
Cinnarizine is known to cause more or less tolerable side effects which are usually transient. These include Depression, Drowsiness, GI upset, Headache, Hypotension , Unsteadiness .
Warnings / Precautions
Available Brands
Storage Conditions
Drug Classification
- 1.12.8 — Other cardiovascular preparations
- 2.24.6 — Cerebrovascular drugs