Caspofungin
Caspofungin is an antifungal agent, active against Aspergillus spp.and Candida spp. Caspofungin is given by intravenous infusion for invasive infection.
Primary Characteristics
It is of Semi Synthetic origin.
Molecular Weight: 10931.31 · Solubility in Water: 3.67e-.1mg/ml · Non-proprietary name: Caspofungin.
Pharmacokinetics
Absorption: Caspofungin has an oral bioavailability is 100%.
Distribution: Caspofungin has a plasma protein binding is 97%.
Elimination: plasma half-life is 9-11 hrs.
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Indications
Caspofungin is primarily indicated in conditions like Gastric acid reduction during anaesthesia, Peritonitis.
Contraindications
Caspofungin is contraindicated in conditions like Hypersensitivity to the drug, Breast feeding.
Dosage
Caspofungin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | Every 24h | IV | An initial dose of 70 mg by i.v.-infusion is given followed by 50 mg i.v. daily. If no response is seen or if inducers of caspofungin clearance are coadministered the daily dose may be increased to 70 mg i.v. An infusion should take approximately 1 hour. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Caspofungin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Fever, Flushing, Headache, Hypersensitivity reactions, Injection-site reactions, Nausea and vomiting, Pruritus , Rashes .
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.6.3 — Antifungal drugs