Capreomycin
Capreomycin is an antimycobacterial cyclic peptide elaborated by Streptococcus capreolus. It consists of four active components its IA, IB, IIA, and IIB. The agent used clinically contains primarily I A and I B. itCapreomycin is given through deep IM (intramuscular) route in the treatment of tuberculosis as part of multidrug regimen, when resistance to or toxicity from primary drugs has developed. Capreomycin is given through deep IM (intramuscular) route. Bacterial resistance to it develops when Capreomycin is given alone.
Primary Characteristics
It is of Semi Synthetic origin.
Molecular Weight: 1324.41 · Non-proprietary name: Capreomycin.
Pharmacokinetics
None recorded.
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Indications
Capreomycin is primarily indicated in conditions like Severe or recurrent duodenal and gastric ulcertion.
Contraindications
Capreomycin is contraindicated in conditions like Allergy, Hypersensitivity to the drug.
Dosage
Capreomycin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1 gm | 1 gm | Every 24h | IM | For treatment of tuberculosis (TB):This dose is given for 60 to 120 days. After this time, 1 gram of capreomycin is injected into the muscle 2 or 3 times a week. This medicine must be given with other medicines to treat tuberculosis (TB). |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Capreomycin is known to cause more or less tolerable side effects which are usually transient. These include Hypersensitivity reactions, Rashes , Urticaria.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.6.2.4 — Anti-tuberculosis drugs