Chorionic Gonadotrophin
Chorionic Gonadotrophin is a hormone produced in placenta. It stimulates the ovaries and the testes. Chorionic Gonadotrophin is used in males to stimulate testicular descent or testicular growth and development. In females, Chorionic Gonadotrophin is used in combination with other medication to induce ovulation.
Primary Characteristics
It is of Natural origin and belongs to Glycoprotein.
It belongs to LH-agonist pharmacological group on the basis of mechanism of action and also classified in Gonadotrophin pharmacological group. It is also classified under Sex Hormones .
Molecular Weight: 100000 · Solubility in Water: freely soluble · Solubility in Alcohol: insoluble · Non-proprietary name: Chorionic Gonadotrophin.
Pharmacokinetics
Absorption: Chorionic Gonadotrophin has an oral bioavailability is 2.5% (±2.5%).
Distribution: Chorionic Gonadotrophin has a volume of distribution is 1.66 litre.
Elimination: it is metabolised via 90% via liver, plasma half-life is 11 hr, renal excretion is major change drug wtih in three days.
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Indications
Chorionic Gonadotrophin is primarily indicated in conditions like Cryptorchidism (undescended testes), Hypogonadotrophic hypogonadism, Idiopathic male infertility, Induction of ovarian follicle maturation.
Contraindications
Chorionic Gonadotrophin is contraindicated in conditions like Precocious puberty, Ovarian hyperstimulation syndrome (OHS), Edema.
Dosage
Chorionic Gonadotrophin's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 7500 IU | 7500 IU | — | IM | According to patient`s response. |
| Paediatric Dosage (20kg) | ||||
| 75 IU/kg | 75 IU/kg | — | Intra Muscular | Alternate days for several weeks, (for boys) |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Not recommended in this age group | |
Drug Interactions
None recorded.
Side Effects
Chorionic Gonadotrophin in overdosage may give rise to further complications which include Precocious puberty .
Chorionic Gonadotrophin produces potentially life-threatening effects which include Ovarian hyperstimulation syndrome (OHSS). Careful monitoring is needed with proper medical management.
Chorionic Gonadotrophin is known to cause more or less tolerable side effects which are usually transient. These include Depression, Edema, Gynecomastia, Headache, Mood changes, Pain at injection site, Reaction at injection site, Restlessness, Tiredness .
Warnings / Precautions
Interference in Pathology
Chorionic Gonadotrophin may interfere in the diagnosis of Interfere with the Pregnancy Test .
Available Brands
Storage Conditions
Drug Classification
- 1.18.6 — Ovulation stimulants