Choline Magnesium Trisalicylate
Choline Magnesium Trisalicylate is a combination of choline salicylate and magnesium salicylate. It relieves mild to moderate pain, reduces fever and inflammation or swelling. Choline Magnesium Trisalicylate is effective in the treatment of gout, rheumatic fever, rheumatoid arthritis and muscle injuries.
Primary Characteristics
It is of Synthetic origin and belongs to Mg HydroxyBenzoic Acid.
It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action. It is also classified under Analgesics and Anti-inflammatory Agents .
Molecular Weight: 539.8 · pKa: 3.96 · Non-proprietary name: Choline Magnesium Trisalicylate.
Pharmacokinetics
Absorption: Choline Magnesium Trisalicylate has an oral bioavailability is 94% (±4%).
Distribution: Choline Magnesium Trisalicylate has a volume of distribution is 0.1-0.2 l/kg. plasma protein binding is 50-90%.
Elimination: it is metabolised via hepatic, plasma half-life is 2-19 hr, renal excretion is rapid.
Advertisement
Indications
Choline Magnesium Trisalicylate is primarily indicated in conditions like Osteoarthritis, Pain, Rheumatoid arthritis, Soft tissue rheumatism.
Contraindications
Choline Magnesium Trisalicylate is contraindicated in conditions like Peptic ulcer, Renal failure, Congestive heart failure.
Dosage
Choline Magnesium Trisalicylate's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 1.5 mg | 1.5 mg | Every 12h | PO | |
| Paediatric Dosage (20kg) | ||||
| 0 – 0 | — | — | Should be avoided | |
| Neonatal Dosage (3kg) | ||||
| 0 – 0 | — | — | Should be avoided | |
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Choline Magnesium Trisalicylate in overdosage may give rise to further complications which include Gastric hemorrhage , Peptic perforation , Peptic ulceration .
Choline Magnesium Trisalicylate produces potentially life-threatening effects which include Anaphylactoid reactions , Allergic reactions, Bronchospasm . Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Choline Magnesium Trisalicylate are Vomiting, Coma, Acute renal failure, Epigastric pain, Hyperventilation, Irritability, Confusion , Electrolyte disturbances, Hyper or hypoglycemia, Hyperpyrexia, Oliguria, Light headedness.
Choline Magnesium Trisalicylate is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, Drowsiness, Fluid retention, Headache, Light headedness, Tinnitus.
Warnings / Precautions
Interference in Pathology
Choline Magnesium Trisalicylate may interfere in the diagnosis of Reversible elevation of hepatic transaminases, alkaline phosphatase. , Reduction of the granulocyte count has been reported. , Urine testing for Bilirubin and Ketones and may produce a false positive test for sugar. .
Available Brands
Click on a strength to view available brands.
Multi-Ingredient Combinations
Storage Conditions
Drug Classification
- 1.27 — Vitamins, minerals, tonics, and other susbstances