Desloratadine
Desloratadine is an active metabolite of loratadine, a non-sedating antihistamine. It causes less sedation and psychomotor impairment than the older antihistamines because it penetrates the blood brain barrier only to a slight extent. Desloratadine is used for the symptomatic relief of allergic conditions such as urticaria and hay fever.
Primary Characteristics
It belongs to H1-antagonist pharmacological group on the basis of mechanism of action.
Non-proprietary name: Desloratadine.
Pharmacokinetics
Elimination: plasma half-life is 27hr.
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Indications
Desloratadine is primarily indicated in conditions like Perennial rhinitis, Urticaria.
Desloratadine is also indicated for secondary conditions like Seasonal allergic rhinitis.
Contraindications
Desloratadine is contraindicated in conditions like Porphyria, Pregnancy, Breast feeding.
Dosage
Desloratadine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 5 mg | 5 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| 1.25 1 | 1.25 1 | — | for 12 months to 5 year. | |
| 2.5 mg | 2.5 mg | Every 24h | for 6 to 11 years | |
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Desloratadine produces potentially life-threatening effects which include Arrhythmias, Anaphylaxis , Angioedema , Extrapyrimidal symptoms. Careful monitoring is needed with proper medical management.
Desloratadine is known to cause more or less tolerable side effects which are usually transient. These include Blurred vision, Drowsiness, Dry mouth, Fatigue, GI disturbance, Headache, Myalgia, Palpitation, Pharyngitis, Urinary retensionX.
Warnings / Precautions
Available Brands
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Single Ingredient
Drug Classification
- 1.3 — Anti-allergics (Antihistamines) and drugs used in anaphylaxis