Tinzaparin Sodium

Drug #1668

Tinzaparin is a low molecular weight heparin. It is used in the prevention of venous thrombo-embolism. It is also used to prevent clotting in the extracorporeal circulation during hemodialysis. In orthopedic practice it is more valuable. It has a longer duration of action.

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Primary Characteristics

Non-proprietary name: Tinzaparin Sodium.

Molecular structure of Tinzaparin Sodium

Pharmacokinetics

None recorded.

Indications

Tinzaparin Sodium is primarily indicated in conditions like Deep vein thrombosis.

Contraindications

Tinzaparin Sodium is contraindicated in conditions like Heparin induced thrombocytopenia, Hypersensitivity to any component of product.

Dosage

Tinzaparin Sodium's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
175 anti-Xa IU/kg of body weight	175 anti-Xa IU/kg of body weight	Every 24h	SC	Should be administered for at least 6 days and until the patient is adequately anticoagulated with warfarin (INR at least 2.0 for two consecutive days). Warfarin sodium therapy should be initiated when appropriate (usually within 1-3 days of Tinzaparin Sodium initiation).
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

6 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Tinzaparin Sodium in overdosage may give rise to further complications which include Angina , Thromboembolism, Hematuria, Cardiac arrhythmias, Hemorrhage, Granulocytopenia .

Tinzaparin Sodium is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anemia, Bleeding , Chest pain, Diarrhea, Headache, Mild local pain around injection site, Nausea, Rashes , Thrombocytopenia, UTI .

Warnings / Precautions

Should not be mixed with other injections or infusions. Should be used with care in patients with a bleeding diathesis, uncontrolled arterial hypertension, or a history of recent gastrointestinal ulceration, diabetic retinopathy and hemorrhage.Tinzaparin Sodium contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown, but is probably low. Sulfite sensitivity is more frequent in asthmatic people than in non-asthmatic people.

Interference in Pathology

Tinzaparin Sodium may interfere in the diagnosis of Elevations of SGPT and SGOT , Hematocrit Value , Elevation in ALT or AST, Stool testing, Complete blood cell count.

Available Brands

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Single Ingredient

Inj

10000 IU/ml

Storage Conditions

Tinzaparin Sodium should be stored Inj.

Drug Classification

1.10.2 — Anticoagulants/Platelet deaggregators

Manufacturers

Manufacturers of Tinzaparin Sodium in Pakistan:

Zam