Moexipril

Drug #1664

Moexipril is an oral angiotensin-converting enzyme (ACE) inhibitor and is used to treat hypertension. Like quinapril and ramipril, the active metabolite is produced by deesterification from the prodrug. Moexiprilat (the deesterified form), is about 1000 times active than moexipril itself and antihypertensive activity entirely depends on this metabolite. Prolonged antihypertensive effects allow for once-daily dosing. The dosage range is halved in patients who are taking diuretics or who have renal impairment. It was approved by FDA on April 19, 1995.

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Primary Characteristics

Moexipril is also known as Moexipril HCl.

Non-proprietary name: Moexipril · pH: 1.5.

Pharmacokinetics

Absorption: Moexipril has an oral bioavailability is 6.5% (±6.5%).

Distribution: Moexipril has a volume of distribution is 0.

Elimination: plasma half-life is 12hr, renal excretion is Urine.

Indications

Moexipril is primarily indicated in conditions like Hypertension.

Contraindications

Moexipril is contraindicated in conditions like Hypersensitivity.

Dosage

Moexipril's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
3.75 mg	3.75 mg	Every 24h	PO	Initial dose: Should be taken 1 hour prior to meals.
18.75 mg/day	18.75 mg/day	Every 24h	PO	Maintenance dose: Should be taken in 1-2 divided doses 1 hour before meals.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

6 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Moexipril in overdosage may give rise to further complications which include Fever , Allergic reactions , Chest pain , Irregular heart beat.

The signs and symptoms that are produced after acute overdosage of Moexipril are fatigue, Dizziness, Fainting , Weakness .

Moexipril is known to cause more or less tolerable side effects which are usually transient. These include Anxiety, Chest pain, Diarrhea, Flushing, Headache, Itching, Nausea, Palpitation, Rashes .

Warnings / Precautions

Use caution when driving as Moexipril may cause dizziness. Use alcohol cautiously as moexipril may further lower blood pressure. Donot use salt substitute or potassium supplements. Cautions should be taken in allergic patients.

Interference in Pathology

Moexipril may interfere in the diagnosis of Increased level of Blood urea nitrogen (BUN) concentrations, Increased in serum creatinin.

Available Brands

None recorded.

Storage Conditions

Moexipril should be stored Any form.

Drug Classification

1.12.3.3 — ACE inhibitors