Interferon Alpha 2a
Interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The interferones bind to specific cell-surface receptors that initiate a series of intracellular events, induction of certain enzymes, inhibition of cell-proliferation, and enhancement of immune activities.The term "interferon alfa" actually refers to at least three compounds that only differ slightly in their amino acid sequence: interferon alfa-2a, interferon alfa-2b , and interferon alfa-n3. Interferon alfa-2a, highly purified protein produced by a recombinant DNA process. interferon alpha 2a is indicated in the treatment of a variety of tumours including hairy cell leukaemia, malignant melanoma, follicular lymphomaand AIDS related Kaposi`s sarcoma. Interferon alfa-2a was approved by the FDA in 1986.
Primary Characteristics
It belongs to Protein(165 aminoacid).
Molecular Weight: 19241.1 · Non-proprietary name: Interferon Alpha 2a.
Pharmacokinetics
Distribution: Interferon Alpha 2a has a volume of distribution is 0.223 to 0.748 L/kg.
Elimination: plasma half-life is 3.7 to 8.5 hours, renal excretion is Major.
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Indications
Interferon Alpha 2a is primarily indicated in conditions like AIDS-related kaposi sarcoma, Chronic hepatitis B infection, Chronic hepatitis C, Chronic myeloid leukaemia, Cutaneous t cell lymphoma, Hairy cell leukaemia.
Contraindications
Interferon Alpha 2a is contraindicated in conditions like Autoimmune hepatitis, Hypersensitivity to any component of product.
Dosage
None recorded.
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Interferon Alpha 2a in overdosage may give rise to further complications which include Alopecia , Fever , Anemia , Anemia , Confusion , Drowsiness , Vasculitis , Neutropenia , Chest pain , Cough , Myalgia , Blurred vision , Myocardial infarction , Anemia, Anemia, Leukopenia, Diabetes mellitus.
Interferon Alpha 2a produces potentially life-threatening effects which include Infection, Ischemic damage. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Interferon Alpha 2a are Coma, fatigue, Lethargy, Prostration .
Interferon Alpha 2a is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Difficulty breathing, Dizziness, Dry mouth, Dry skin, Hives, Insomnia, Irritability, Nausea, vomiting, sweating, and diarrhea (when ingested ), Vertigo, Weight loss, Wheezing .
Warnings / Precautions
Interference in Pathology
Interferon Alpha 2a may interfere in the diagnosis of Thyroid Function Test, Hematocrit Value .
Available Brands
Storage Conditions
Drug Classification
- 1.8.1 — Immunomodulators