Tegaserod
A newer 5 HT-4 partial agonist. It is used in the treatment of patients with irritable bowel syndrome with predominant constipation. Tegaserod appears to be an extremely safe agent.
Primary Characteristics
It is of Synthetic origin.
It belongs to GI Serotonin receptor agonist pharmacological group on the basis of mechanism of action.
Non-proprietary name: Tegaserod.
Pharmacokinetics
Distribution: Tegaserod has a volume of distribution is 368±223L. plasma protein binding is 98%.
Elimination: plasma half-life is 11±5hrs.
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Indications
Tegaserod is primarily indicated in conditions like Abdominal discomfort, Abdominal pain, Constipation, Irritable bowel syndrome.
Contraindications
Tegaserod is contraindicated in conditions like Hypersensitivity.
Dosage
Tegaserod's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 6 mg | 6 mg | Every 12h | PO | Before Meals (Breakfast & Dinner) for 1 month |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Tegaserod is known to cause more or less tolerable side effects which are usually transient. These include Backache , Diarrhea, Dizziness, Flatulence, Headache, Influenza like syndrome , Nausea.
Warnings / Precautions
Interference in Pathology
Tegaserod may interfere in the diagnosis of Elevations of SGPT and SGOT , Increased concentration of creatinine kinase.
Available Brands
Storage Conditions
Drug Classification
- 1.17.6 — Laxatives