Hepatitis B Vaccine
Also known as: Engerix-B vaccone, Recombivax HB vaccine, H-B-Vax 2 vaccine
Hepatitis B Vaccine is a sterile preparation containing particles of hepatitis surface antigen (HBsAg). There are two types of vaccines available each containing hepatitis surface antigen (HBsAg) adsorbed onto alluminium hydroxide. In one type of vaccine the surface antigen is obtained from plasma after purification and inactivation processes and in the second type the surface antigen is produced in yeast cells using recombinaant DNA techniques. Hepatitis B vaccines are used for the active immunisation against hepatitis B infections.
Primary Characteristics
Hepatitis B Vaccine is also known as Engerix-B vaccone, Recombivax HB vaccine, H-B-Vax 2 vaccine.
It is of Semi Synthetic origin and belongs to Aluminium hydroxide.
Molecular Weight: 24 · Non-proprietary name: Hepatitis B Vaccine.
Pharmacokinetics
Elimination: it is metabolised via reticulsoendothelial.
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Indications
Hepatitis B Vaccine is primarily indicated in conditions like Hepatitis B prophylaxis.
Hepatitis B Vaccine is also indicated for secondary conditions like Immunocompromised patient.
Contraindications
Hepatitis B Vaccine is contraindicated in conditions like Hypersensitivity, Acute severe febrile illness.
Dosage
Hepatitis B Vaccine's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 10 – 20 ug | — | — | IM | Or 1ml. A series of three IM injections at 0, 1 and 2 months or 0, 1 and 6 months is required to achieve the optimal protection. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
None recorded.
Side Effects
Hepatitis B Vaccine in overdosage may give rise to further complications which include Convulsions , Neuropathy , Angioedema , Angioedema , Meningitis , Anaphylactic reactions , Paralysis.
Hepatitis B Vaccine produces potentially life-threatening effects which include Anaphylactic reactions. Careful monitoring is needed with proper medical management.
Hepatitis B Vaccine is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Arthralgia, Diarrhea, Dizziness, Fatigue, Fever, Headache, Hypotension , Malaise, Myalgia, Nausea, Pain , Paralysis , Paresthesias, Pruritus , Rashes , Redness, Swelling at injection site, Syncope , Vomiting , Weakness.
Warnings / Precautions
Interference in Pathology
Hepatitis B Vaccine may interfere in the diagnosis of hepatitis A,C and E.
Available Brands
Storage Conditions
Drug Classification
- 1.19.3.1 — Vaccines for universal immunization