Itopride (HCl)
Itopride (HCl) is a substituted benzamide, which is used for its prokinetic and antiemetic properties. The actions, uses and adverse effects similar to that of metaclopramide.
Primary Characteristics
Itopride (HCl) is also known as Itopride.
It belongs to Benzamide.
Molecular Weight: 394.9 · Non-proprietary name: Itopride (HCl).
Pharmacokinetics
Absorption: Itopride (HCl) has an oral bioavailability is 30% (±30%).
Distribution: Itopride (HCl) has a plasma protein binding is 96%.
Elimination: it is metabolised via Hepatic, renal excretion is Urine.
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Indications
Itopride (HCl) is primarily indicated in conditions like Dyspepsia, Gastro-esophageal reflux disease, Nausea and vomiting.
Itopride (HCl) is also indicated for secondary conditions like Anorexia, Heart burn.
Contraindications
Itopride (HCl) is contraindicated in conditions like Parkinson's disease, Hypersensitivity to any component of product, Gastrointestinal hemorrhage.
Dosage
Itopride (HCl)'s dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | Every 8h | PO | Should be taken before meal. |
| 150 mg | 150 mg | Every 24h | PO | |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Itopride (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Constipation , Diarrhea, Dizziness, Headache, Leucopenia, Redness, Thrombocytopenia, Tremor.
Warnings / Precautions
Interference in Pathology
Itopride (HCl) may interfere in the diagnosis of Elevations of SGPT and SGOT , Increased Alkaline Phosphatase Levels, Elevation in ALT or AST.
Available Brands
Storage Conditions
Drug Classification
- 1.17.2 — Antiemetics & antinauseants
Manufacturers
Manufacturers of Itopride (HCl) in Pakistan: