Insulin Lispro

Drug #1585

Insulin Lispro is a recombinant human insulin analogue. Insulin Lispro is used in the treatment of diabetes mellitus. It has a faster onset and shorter duration of action than soluble insulin.

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Primary Characteristics

It is of Semi Synthetic origin and belongs to Polypeptide.

Molecular Weight: 5808 · Non-proprietary name: Insulin Lispro · pH: 7.

Pharmacokinetics

Distribution: Insulin Lispro has a volume of distribution is 0.26-0.36L/kg.

Elimination: it is metabolised via identical to that of regular human insulin., plasma half-life is 1hr.

Indications

Insulin Lispro is primarily indicated in conditions like Iddm, Type II diabetes mellitus.

Contraindications

Insulin Lispro is contraindicated in conditions like Hypoglycaemia, Hypersensitivity to any component of product.

Dosage

Insulin Lispro's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.3 units/kg/day	0.3 units/kg/day	—	SC	The dosage of insulin lispro must be individualized. Blood glucose monitoring is essential in all patients receiving insulin therapy. It may be administered by continuous subcutaneous infusion by an external insulin pump. Do not use diluted or mixed insulins in external insulin pumps. Infusion sites should be rotated within the same region to reduce the risk of lipodystrophy . Change insulin lispro in the reservoir at least every 7 days, change the infusion sets and the infusion set insertion site at least every 3 days.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown13 interactions

3 interactions

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Insulin Lispro in overdosage may give rise to further complications which include Wheezing , Hypoglycemia, Hives, Lipoatrophy, Muscle Cramps, Difficulty in breathing.

The signs and symptoms that are produced after acute overdosage of Insulin Lispro are Coma.

Insulin Lispro is known to cause more or less tolerable side effects which are usually transient. These include Allergic reactions, Constipation , Cough , Headache, Infection, Peripheral edema, Pharyngitis, Redness, Rhinitis , Swelling at injection site, Swelling of feet.

Warnings / Precautions

Hypoglycemia is the most common adverse effect associated with insulins, including insulin lispro. As with all insulins, the timing of hypoglycemia may differ among various insulin formulations. Glucose monitoring is recommended for all patients with diabetes. Any change of insulin should be made cautiously and only under medical supervision. The requirements for insulin may be reduced in patients with renal impairment. Although impaired hepatic function does not affect the absorption or disposition of insulin lispro, careful glucose monitoring and dose adjustments of insulin, including Humalog, may be necessary.

Interference in Pathology

Insulin Lispro may interfere in the diagnosis of Monitoring of blood and urine glucose.

Available Brands

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Single Ingredient

Inj

100 IU/ml

Multi-Ingredient Combinations

Inj

25 %w/v 50 %w/v

Drug Classification

1.18.7.1 — Insulins

Manufacturers

Manufacturers of Insulin Lispro in Pakistan:

Lilly