Cilostazole
Cilostazole is a vasodilator and an inhibitor of platelet agreggation. Cilostazole is used in the management of some peripheral vascular disorders.Cilostozol is a newer phosphodiesterase inhibitor that promotes vasodilation and inhibition of platelet aggregation. cilostozol is used primary to treat intermittant claudication.
Primary Characteristics
It is of Synthetic origin and belongs to Quinolinone.
Molecular Weight: 369.5 · Non-proprietary name: Cilostazole.
Pharmacokinetics
Distribution: Cilostazole has a plasma protein binding is 95 to 98%.
Elimination: it is metabolised via extensivity in liver, plasma half-life is 11-13hr, renal excretion is 74%.
Advertisement
Indications
Cilostazole is primarily indicated in conditions like Intermittant claudication, Long-term treatment of reflux oesophagitis, Peripheral vascular disease.
Cilostazole is also indicated for secondary conditions like Secondary prevention of ischaemic stroke and tias.
Contraindications
None recorded.
Dosage
Cilostazole's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 100 mg | 100 mg | Every 12h | PO | Should be taken 30 min before or 2 hours after breakfast and dinner. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Cilostazole in overdosage may give rise to further complications which include Angina , Oedema , Palpitation , Rhinitis , Rhinitis , Abnormal stools.
The signs and symptoms that are produced after acute overdosage of Cilostazole are Cardiac arrhythmias, Tachycardia , Diarrhea, Hypotension.
Cilostazole is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea, Dizziness, Headache, Irregular heart beat, Palpitation, Rashes , Shortening of breath, Sore throat.
Warnings / Precautions
Interference in Pathology
Cilostazole may interfere in the diagnosis of Abnormal LFTs , Increased blood glucose level.
Available Brands
Storage Conditions
Drug Classification
- 1.12.8 — Other cardiovascular preparations