Mivacurium (Cl)

Drug #1564

Mivacurium (Cl) is a benzylisoquinolinium, a competative neuromuscular blocker similar to atracurium. Mivacurium (Cl) is used to produce muscle relaxation in general anaesthesia for surgical procedures and also to assist mechanical ventilation. It has a short duration of action than most other competitive neuromuscular blockers. Mivacurium (Cl) is metabolised by plasma cholinestarase and muscle paralysis is prolonged in individuals deficient in this enzyme. Mivacurium (Cl) is not associated with parasympatholytic or ganglionic blockade although histamine release may occur, perticularly with rapid injection.

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Primary Characteristics

It is of Synthetic origin and belongs to Benzylesoqiunolinium.

Molecular Weight: 1100.2 · Solubility in Water: high · Non-proprietary name: Mivacurium (Cl).

Pharmacokinetics

Absorption: Mivacurium (Cl) has an pre-systemic (first-pass) metabolism accounts for 15% (±15%).

Distribution: Mivacurium (Cl) has a volume of distribution is 0.1 - 0.3 l/Kg.

Elimination: plasma half-life is 5 min.

Indications

Mivacurium (Cl) is primarily indicated in conditions like Adjunct to anesthesia, Muscle relaxation, Muscle relaxation (short duration) for surgery.

Contraindications

Mivacurium (Cl) is contraindicated in conditions like Hypersensitivity, Cholinesterase deficiency.

Dosage

Mivacurium (Cl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
100 ug/kg	100 ug/kg	—	IV	Maintaenance dose should be given at 15 min interval.
160 ug/kg	160 ug/kg	—	IV	Initial dose
Paediatric Dosage (20kg)
100 ug/kg	100 ug/kg	—		Every 6-9 month (maintnance dose)
200 ug/kg	200 ug/kg	—		Initial
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown11 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Mivacurium (Cl) produces potentially life-threatening effects which include Hypotension, Bronchospasm , Bronchospasm, Erythema, Prolongation of neuromuscular blockade. Careful monitoring is needed with proper medical management.

The signs and symptoms that are produced after acute overdosage of Mivacurium (Cl) are Hypotension, Apnea, Paralysis of respiratory muscle , Flaccid paralysis..

Warnings / Precautions

Use with caution in patients with bronchial asthma. Exercise special caution, especially when histamine release would be hazardous, especially in patients with significant cardiovascular diseases. It should be used with cuation in pateints with plasma cholinesterase deficiency.

Available Brands

None recorded.

Storage Conditions

Mivacurium (Cl) should be stored IV Inj, IV Inf.

Drug Classification

1.20 — Muscle relaxants and cholinesterase inhibitors