Loracarbef

Drug #1561

Loracarbef is an antibiotic, belongs to new class of beta-lactams, the carbacephins. Loracarbef is a synthetic structural analogue of cefaclor (a second-generation cephalosporin), but more stable against ß-lactamases. it's antimicrobial spectrum is similar to that of cefaclor. The clinical efficacy of Loracarbef is comparable to that of amoxicillin and amoxicillin/clavulanic acid in patients with upper or lower respiratory tract infections and is also comparable to cefaclor in treating patients with lower respiratory tract, skin, skin structure, and urinary tract infections. It was approved by FDA in December 1991.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 367.8 · pK_a: 2 · Solubility in Water: 1 in 10 · Non-proprietary name: Loracarbef.

Pharmacokinetics

Absorption: Loracarbef has an oral bioavailability is 90%.

Distribution: Loracarbef has a volume of distribution is 0.3-0.4 l/kg. plasma protein binding is 25%.

Elimination: plasma half-life is 1 hr, renal excretion is Urine (Unchanged).

Indications

Loracarbef is primarily indicated in conditions like Acute bacterial pneumonia, Acute maxillary sinusitis, Acute pharyngitis, Acute tonsillitis, Hormone-mediated secretory diarrhea (can be benefit in refactory cases), Otitis media, Secondry bacterial infection of acute bronchitis, Sinusitis, Skin infections, Skin structure infections, UTI.

Contraindications

Loracarbef is contraindicated in conditions like Hypersensitivity.

Dosage

Loracarbef's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
200 mg	200 mg	Every 12h	PO	For skin and soft tissue infections: Should be given for 7 days.
200 mg	200 mg	Every 12h	PO	For streptococcal pharyngitis: Should be given for 10 days.
300 mg	300 mg	Every 12h	PO	For urinary tract infections: Should be given for 7-14 days.
300 mg	300 mg	Every 12h	PO	For bronchitis: Should be given for 7 days.
400 mg	400 mg	Every 12h	PO	For Pneumonia: Should be given for 14 days.
400 mg	400 mg	Every 12h	PO	For Sinusitis: Should be given for 10 days.
Paediatric Dosage (20kg)
7.5 mg/kg	7.5 mg/kg	Every 12h		For uncomplicated infections.
15 mg/kg	15 mg/kg	Every 12h		Otitis nedia.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Loracarbef in overdosage may give rise to further complications which include Thrombocytopenia , Maculopapular rash , Leukopenia, Pseudomembranous colitis , Eosinophilia .

Loracarbef produces potentially life-threatening effects which include Acute intestinal nephritis. Careful monitoring is needed with proper medical management.

Loracarbef is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Anorexia , Diarrhea, Dizziness, Headache, Rashes , Vomiting .

Warnings / Precautions

Loracarbef should not be given to patients known to be hypersensitive to it or to other beta-lactams because of the possibility of cross-sensitivity. It should be used cautiously in patients with impaired renal function. A reduction in dose may be required. Renal and hematological status should be monitored during prolonged and high dose therapy.

Interference in Pathology

Loracarbef may interfere in the diagnosis of +ve Coomb`s tests, Elevation of LDH.

Available Brands

None recorded.

Storage Conditions

Loracarbef should be stored Cap, Susp.

Drug Classification

1.6.2.1.3 — Cephalosporins