Chenodeoxycholic Acid

Drug #155

Chenodeoxycholic Acid is a natural occuring bile acid. It prevents formation and helps in dissolution of gall stones.

Primary Characteristics

Chenodeoxycholic Acid is also known as chenodial, chenic acid.

It is of Semi Synthetic origin and belongs to Steroid.

It belongs to Bile solubiliser (GI) pharmacological group on the basis of mechanism of action and also classified in Antilipemic Agent pharmacological group. It is also classified under Histamine (H-2) Antagonists .

Molecular Weight: 392.6 · pK_a: 6.5 · Solubility in Water: almost insoluble · Solubility in Alcohol: high · Non-proprietary name: Chenodeoxycholic Acid.

Molecular structure of Chenodeoxycholic Acid

Pharmacokinetics

Absorption: Chenodeoxycholic Acid has an oral bioavailability is 100%, pre-systemic (first-pass) metabolism accounts for 62%.

Distribution: Chenodeoxycholic Acid has a volume of distribution is low. plasma protein binding is 96-99%.

Elimination: it is metabolised via hepatic.

Indications

Chenodeoxycholic Acid is primarily indicated in conditions like Cerebrotendinous xanthomatosis, Gall stones.

Contraindications

Chenodeoxycholic Acid is contraindicated in conditions like Calcified gallstones, Chronic liver disease, Non-functioning gallbladders.

Dosage

Chenodeoxycholic Acid's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
14 mg/kg	14 mg/kg	—	PO	Maintainence dose.Given in two divided doses
250 mg	250 mg	Every 12h	PO	Initial dose given for 2 weeks .Should be taken with food.
Paediatric Dosage (20kg)
0 – 0	—	—	—	Not Recommended in this Age Group
Neonatal Dosage (3kg)
0 – 0	—	—		Not recommended in this age group

Drug Interactions

Unknown3 interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Chenodeoxycholic Acid in overdosage may give rise to further complications which include Hepatotoxicity , Hepatotoxicity , hypertransaminasemia, Hypertransaminasemia.

Chenodeoxycholic Acid produces potentially life-threatening effects which include Colonic cancer. Careful monitoring is needed with proper medical management.

Chenodeoxycholic Acid is known to cause more or less tolerable side effects which are usually transient. These include Diarrhea.

Warnings / Precautions

Chenodeoxycholic acid should not be administered to patients with chronic liver disease, peptic ulcer or inflammatory bowl disease. Its use should be avoided in pregnancy.

Available Brands

None recorded.

Storage Conditions

Chenodeoxycholic Acid should be stored Tabs.

Drug Classification

1.12.8 — Other cardiovascular preparations