Tolrestat
Primary Characteristics
It is of Synthetic origin.
Molecular Weight: 357.4 · pKa: 3 · Solubility in Water: 1 in 6700 · Solubility in Alcohol: 1 in 120 · Non-proprietary name: Tolrestat.
Pharmacokinetics
Absorption: Tolrestat has an oral bioavailability is 66% (±3%).
Distribution: Tolrestat has a volume of distribution is 20 litre. plasma protein binding is 99.5 %.
Elimination: plasma half-life is 10 hr, renal excretion is 69 % unchanged.
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Indications
Tolrestat is primarily indicated in conditions like Diabetic retinopathy.
Contraindications
Tolrestat is contraindicated in conditions like Renal failure, Liver diseases, Pregnancy, Lactation.
Dosage
None recorded.
Drug Interactions
None recorded.
Side Effects
Tolrestat in overdosage may give rise to further complications which include Hepatotoxicity .
Tolrestat is known to cause more or less tolerable side effects which are usually transient. These include Dizziness.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.99 — Unassigned