Zotepine
An atypical antipsychotic, used to treat schizophrenia. It has less extrapyramidal symptoms as compared to old antipsychotics.
Primary Characteristics
It is of Synthetic origin and belongs to Dibenzothiepine.
Molecular Weight: 331.87 · Solubility in Water: Insoluble · Solubility in Alcohol: slight · Non-proprietary name: Zotepine.
Pharmacokinetics
Absorption: Zotepine has an pre-systemic (first-pass) metabolism accounts for 85% (±5%).
Distribution: Zotepine has a volume of distribution is 10 l/Kg. plasma protein binding is ~ 97 %.
Elimination: plasma half-life is 12 - 24 hr, renal excretion is 0.1 % unchanged.
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Indications
Zotepine is primarily indicated in conditions like Schizophrenia, Schizophreniform psychoses.
Contraindications
Zotepine is contraindicated in conditions like Cardiac arrhythmia, Hypertension, Convulsions, Hypotension, Narrow-angle glaucoma, Hypersensitivity, Intoxication with alcohol, Hematopoietic disorder, Urinary retention.
Dosage
None recorded.
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Zotepine in overdosage may give rise to further complications which include Seizures .
Zotepine produces potentially life-threatening effects which include Muscle rigidity, Neuroleptic Malignant Syndrome , Akinesia, Hyperpyrexia. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Zotepine are Hypotension, Cardiac arrhythmias, Coma, Respiratory depression, Agitation, Extrapyramidal effects , Tachycardia , Convulsions , Seizures, Hypothermia, Cardiovascular collapse.
Zotepine is known to cause more or less tolerable side effects which are usually transient. These include Akathisia, Dizziness, Dry mouth, Dyskinesia , Extrapyramidal effects, Fatigue, Headache, Hot flushes, Orthostatic hypotension, Parkinsonism, Respiratory depression, Sedation , Tachycardia, Weight gain.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.24.1 — Drugs used in psychotic disorders