Zileuton

Drug #1496

Zileuton is a lipoxygenase inhibitor that has been used in asthma but is not as popular as the receptor inhibitor. It works by blocking the formation of substances that cause inflammation, fluid retention, mucous secretion, and constriction in lungs

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 236.3 · Non-proprietary name: Zileuton.

Pharmacokinetics

Distribution: Zileuton has a plasma protein binding is 93 %.

Elimination: plasma half-life is 2 hr.

Indications

Zileuton is primarily indicated in conditions like Asthma.

Contraindications

None recorded.

Dosage

None recorded.

Drug Interactions

Unknown1 interaction

Moderate1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Zileuton in overdosage may give rise to further complications which include Leucopenia, Raised liver enzyme activity .

Zileuton is known to cause more or less tolerable side effects which are usually transient. These include GI disturbance, Head stroke, Urticaria.

Warnings / Precautions

It should not be used in patients with hepatic impairment or active liver disease. It is not suitable for the treatemnt of acute asthma attacks.

Available Brands

None recorded.

Storage Conditions

Zileuton should be stored Tab.

Drug Classification

1.25.1.1 — Oral/Parenteral antiasthmatics