Nafcillin

Drug #1490

Nafcillin is a semisynthetic penicillin, which is highly resistant to penicillanase enzyme, with uses, actions similar to those of flucloxacillin. Nafcillin is used in the treatment of infections caused by penicillinase-producing strains of staphylococci, that are resistant to benzylpenicillin.

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Primary Characteristics

Nafcillin is also known as Nafcillin Sodium.

It is of Synthetic origin.

Molecular Weight: 454.5 · pK_a: 13.98 · Solubility in Water: freely soluble · Solubility in Alcohol: soluble · Non-proprietary name: Nafcillin · pH: 5.

Pharmacokinetics

Distribution: Nafcillin has a plasma protein binding is 90 %.

Elimination: it is metabolised via hepatic, plasma half-life is 0.5 - 1 hr, renal excretion is 30 %.

Indications

Nafcillin is primarily indicated in conditions like Bone and joint infection, Endocarditis, Skin infections, Staphylococcal infections.

Contraindications

Nafcillin is contraindicated in conditions like Hypersensitivity.

Dosage

Nafcillin's dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
0.75 g	0.75 g	Every 4h	IV	By slow injection over 5 to 10 minutes or by slow infussion over at least 30 to 60 minutes for not more than 24 to 48 hr
500 mg	500 mg	—	IV	drug shoud be given 4 to 5 times a day
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown3 interactions

3 interactions

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Nafcillin in overdosage may give rise to further complications which include Hemolytic anemia , Hypotension , Thrombophlebitis , Pruritis , Cholestatic jaundice , Hemolytic anemia , Hepatitis , Bronchospasm , Urticaria , Neutropenia , Prolongation of bleeding time .

Nafcillin produces potentially life-threatening effects which include Convulsions , CNS toxicity, Anaphylaxis . Careful monitoring is needed with proper medical management.

Nafcillin is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Hypersensitivity reactions, Inflammation, Pain , Rashes , Skin RashX, Swelling , Wheezing .

Warnings / Precautions

It should be used with caution in patients with history of allergy, especially to drugs and in patient hypersensitive to penicillin. Care is necessary if very high dose of penicillin is given, especially if renal function is poor. Renal and hematological status should be monitored during prolonged and high dose therapy.

Interference in Pathology

Nafcillin may interfere in the diagnosis of Urinanalysis , Liver Function Tests , Periodic BUN and creatinine determinations.

Available Brands

None recorded.

Storage Conditions

Nafcillin should be stored Inj (after reconstitution). Tab, Caps.

Drug Classification

1.6.2.1.1 — Penicillins