Glucagon (HCl)

Drug #1487

Glucagon (HCl) is a polypeptide hormone that is produced by alpha-cells of pancreas. Glucagon (HCl) is a hyperglycaemic (increases blood glucose level) that mobilises glucose by activating glycogenolysis. It causes release of several other hormones, and also increases cardiac muscles contraction. Glucagon (HCl) is used in tests of carbohydrate metabolism and also for the management beta-blocker overdosage.

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Primary Characteristics

It is of Natural origin.

Molecular Weight: 3482.8 · Solubility in Water: insoluble · Non-proprietary name: Glucagon (HCl).

Pharmacokinetics

Elimination: plasma half-life is 3 -6 min.

Indications

Glucagon (HCl) is primarily indicated in conditions like Severe hypoglycemic reactions.

Glucagon (HCl) is also indicated for secondary conditions like Poisoning.

Contraindications

Glucagon (HCl) is contraindicated in conditions like Phaeochromocytoma.

Dosage

Glucagon (HCl)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
1 – 2 mg	—	—	IM	As a diagnostic aid
0 – 1 mg	—	—	IV/SC/IM	Severe Hypoglycaemia
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

Unknown1 interaction

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Glucagon (HCl) in overdosage may give rise to further complications which include Hypokalemia .

Glucagon (HCl) is known to cause more or less tolerable side effects which are usually transient. These include Abdominal pain, Hypersensitivity reactions, Hypotension , Nausea and vomiting.

Warnings / Precautions

It should be administered with caution to patient with insolinoma as it may induce hypoglycemia due to its insline releasing effects. Caution is also required when it is being employed as a diagnostic aid in diabetic patients. Glucagon is not effective in patients with marked depletion of liver glycogen stores, as in starvation, adrenal insufficiency or chronic hypoglycemia. Should be cautiously given in adrenal insufficiency.

Interference in Pathology

Glucagon (HCl) may interfere in the diagnosis of Serum glucose level.

Available Brands

None recorded.

Storage Conditions

Glucagon (HCl) should be stored . Inj (reconstituted soln).

Drug Classification

1.18.13 — Drugs used in hypoglycemia