Aminocaproic Acid
Aminocaproic Acid is an antifibrinolytic, and a haemostatic agent. It binds to lysine-binding sites within the plasminogen/plasmin molecule. This interferes with the ability of plasmin to lyse fibrin clots. Aminocaproic Acid is used in the treatment of systemic or urinary hyperfibrinolysis, such as may be encountered with disorders such as aplastic anaemia, abruptio placentae, hepatic cirrhosis, neoplastic disease such as carcinoma of the prostate, lung, stomach, or cervix, and following cardiac surgery (with or without by-pass procedures).
Primary Characteristics
It is of Synthetic origin.
Molecular Weight: 131.2 · pKa: 4.43 · Solubility in Water: 1 in 3 · Solubility in Alcohol: slighty · Non-proprietary name: Aminocaproic Acid · pH: 7.5.
Pharmacokinetics
Elimination: plasma half-life is 2 hrs.
Advertisement
Indications
Aminocaproic Acid is primarily indicated in conditions like Acute spasm and spasm in diagnostic procedures, Haemorrhage.
Contraindications
None recorded.
Dosage
None recorded.
Drug Interactions
None recorded.
Side Effects
Aminocaproic Acid in overdosage may give rise to further complications which include Cardiac arrhythmias, Hypotension , Bradycardia .
Aminocaproic Acid produces potentially life-threatening effects which include Convulsions , Cardiac & hepatic damage. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Aminocaproic Acid are Renal failure, Muscle damage.
Aminocaproic Acid is known to cause more or less tolerable side effects which are usually transient. These include Dizziness, GI disturbance, Headache, Nasal congestion , Skin RashX, Tinnitus.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.10.3 — Antihemorrhagics/Antihemophilics