Amrinone (Lactate)

Drug #1478

Amrinone (Lactate) is a vasodilator with positive inotropic properties, belongs to phosphodisterase inhibitors. Amrinone (Lactate) is used for the short term management of heart failure unresponsive to other forms of therapy. The mechanism of action has not been fully determined , however it appears to involve an increase in cAMP concentration due to inhibition of phosphodisterase leading to an increased contractile force in cardiac muscle. Amrinone (Lactate) is given by intravenous route.

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Primary Characteristics

It is of Synthetic origin.

Molecular Weight: 277.3 · Non-proprietary name: Amrinone (Lactate).

Molecular structure of Amrinone (Lactate)

Pharmacokinetics

Distribution: Amrinone (Lactate) has a plasma protein binding is 10-49%.

Elimination: it is metabolised via Hepatic, plasma half-life is 4 hr (6 hr in patient with heart failure), renal excretion is 40% (unchanged).

Indications

Amrinone (Lactate) is primarily indicated in conditions like Heart failure.

Contraindications

Amrinone (Lactate) is contraindicated in conditions like Hypersensitivity to the drug.

Dosage

Amrinone (Lactate)'s dosage details are as follows:

Dose	Single Dose	Frequency	Route	Instructions
Adult Dosage
7.5 mcg per kg of body weight per minute	7.5 mcg per kg of body weight per minute	—	IV	Ths is maintanance dose. the dose should be adjusted according to clinical response. Up to 10 mg (base) per kg of body weight per day, although some patients have been given doses up to 18 mg per kg per day for short durations.
750 mcg per kg of body weight.	750 mcg per kg of body weight.	—	IV	Ths is initial dose and is given undiluted slowly over 2-3 mnutes;may be repeated after 30 minutes if necessary.
Paediatric Dosage (20kg)
No data.
Neonatal Dosage (3kg)
No data.

Drug Interactions

1 interaction

Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Side Effects

Amrinone (Lactate) in overdosage may give rise to further complications which include Cardiac arrhythmias, Hepatosplenomegaly, Hypotension , Hepatosplenomegaly .

The signs and symptoms that are produced after acute overdosage of Amrinone (Lactate) are Thrombocytopenia .

Amrinone (Lactate) is known to cause more or less tolerable side effects which are usually transient. These include Chest pain, Fever, GI disturbance, Headache, Hypersensitivity reactions, Local pain, Nail discoloration.

Warnings / Precautions

It should be used cautiously in severe obstructive aortic or pulmonary valvular disease or in hypertrophic cardiomyopathy. Blood pressure and heart rate should be monitored during parentral administration. The fluid and electrolyte balnace should be maintained. Platelet counts and liver function should also be monitored.

Interference in Pathology

Amrinone (Lactate) may interfere in the diagnosis of Decreased potassium serum concentrations, Increased hepatic enzyme concentrations..

Available Brands

None recorded.

Storage Conditions

Amrinone (Lactate) should be stored Inj.

Drug Classification

1.12.4 — Drugs used in heart failure