Gallopamil
Also known as: Methoxy verapamil hydrochloride
Gallopamil is a derivative of verapamil, a calcium channel blocking drug. It decreases coronary vascular resistance and increases coronary blood flow. Gallopamil is used in myocardial infarction (MI), angina pectoris and cardiac arrhythmias.
Primary Characteristics
Gallopamil is also known as Methoxy verapamil hydrochloride.
It is of Synthetic origin and belongs to Phenyl alkylamine derivative.
Molecular Weight: 521.1 · Solubility in Water: low · Solubility in Alcohol: high · Non-proprietary name: Gallopamil.
Pharmacokinetics
Absorption: Gallopamil has an oral bioavailability is 45% (±45%), pre-systemic (first-pass) metabolism accounts for 40% (±40%).
Distribution: Gallopamil has a volume of distribution is 145 litre. plasma protein binding is 85 - 90 %.
Elimination: plasma half-life is 2.5 - 5.5 hr, renal excretion is < 1% unchanged.
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Indications
Gallopamil is primarily indicated in conditions like Angina, Cardiac arrhythmia, Hypertension.
Contraindications
Gallopamil is contraindicated in conditions like Heart failure, Cardiogenic shock, Hypotension, Atrial fibrillation, Sick sinus syndrome, Atrioventricular block, Renal insufficiency, Hepatic insufficiency.
Dosage
Gallopamil's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 25 – 50 mg | — | Every 12h | IV | The minimum dosage interval should be of 6 h. |
| 50 mg | 50 mg | Every 8h | Oral | Bolus dose of 30-60 µg/kg. |
| 100 mg | 100 mg | Every 12h | SR | Followed by continuous inf of 0.3-1 µg/kg/min |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Gallopamil in overdosage may give rise to further complications which include Worsening of left heart failure.
Gallopamil produces potentially life-threatening effects which include Congestive failure. Careful monitoring is needed with proper medical management.
The signs and symptoms that are produced after acute overdosage of Gallopamil are Hypotension, Orthostatic hypotension, Cardiogenic shock, Change in atrioventricular conduction.
Gallopamil is known to cause more or less tolerable side effects which are usually transient. These include Bradycardia , Constipation , Dry mouth, Epigastric pain, First and second degree heart block, Flushing, Headache, Heat sensation, Nausea, Nervousness, Orthostatic hypotension, Peripheral edema, Weakness.
Warnings / Precautions
Available Brands
None recorded.
Storage Conditions
Drug Classification
- 1.12.3.2 — Calcium antagonists