Bicalutamide
Bicalutamide is an anti-androgen, used for prostate cancer either alone or as an adjunct to other therapy, according to the clinical circumstances. It inhibits the tumour "flare"which may occur after commencing gonadorelin analogue (e.g diethylstilbestrol) administration.
Primary Characteristics
It is of Synthetic origin and belongs to Non Steroidal Antiandrogen.
Molecular Weight: 430.4 · Solubility in Water: insoluble · Solubility in Alcohol: slightly · Non-proprietary name: Bicalutamide.
Pharmacokinetics
Distribution: Bicalutamide has a plasma protein binding is 96%.
Elimination: plasma half-life is 7-10 days, renal excretion is 1.4-2%.
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Indications
Bicalutamide is primarily indicated in conditions like Prostatic cancer.
Bicalutamide is also indicated for secondary conditions like Prostate cancer.
Contraindications
Bicalutamide is contraindicated in conditions like Hypersensitivity.
Dosage
Bicalutamide's dosage details are as follows:
| Dose | Single Dose | Frequency | Route | Instructions |
|---|---|---|---|---|
| Adult Dosage | ||||
| 50 mg | 50 mg | — | PO | Daily with orchidectomy or gonadorelin therapy. |
| Paediatric Dosage (20kg) | ||||
| No data. | ||||
| Neonatal Dosage (3kg) | ||||
| No data. | ||||
Drug Interactions
Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Side Effects
Bicalutamide in overdosage may give rise to further complications which include Angina , Congestive heart failure .
Bicalutamide is known to cause more or less tolerable side effects which are usually transient. These include Anorexia , Anxiety, Chills, Confusion, Cough , Depression, Diarrhea, Dizziness, Dyspepsia , Fatigue, Fever, Hot flushes, Nausea, Nervousness, Rashes , Somnolence , Tiredness , Vomiting , Weight gain, Xerostomia .
Warnings / Precautions
Available Brands
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Single Ingredient
Storage Conditions
Drug Classification
- 1.8.3 — Hormones and antihormones